The stem cell–specific protein TRIM71 inhibits maturation and activity of the prodifferentiation miRNA let-7 via two independent molecular mechanisms

The stem cell–specific RNA-binding protein TRIM71/LIN-41 was the first identified target of the prodifferentiation and tumor suppressor miRNA let-7. TRIM71 has essential functions in embryonic development and a proposed oncogenic role in several cancer types, such as hepatocellular carcinoma. Here,...

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Detalles Bibliográficos
Autores principales: Torres-Fernández, Lucia A., Mitschka, Sibylle, Ulas, Thomas, Weise, Stefan, Dahm, Kilian, Becker, Matthias, Händler, Kristian, Beyer, Marc, Windhausen, Julia, Schultze, Joachim L., Kolanus, Waldemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208056/
https://www.ncbi.nlm.nih.gov/pubmed/33975917
http://dx.doi.org/10.1261/rna.078696.121

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