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Monitoring electron energies during FLASH irradiations

When relativistic electrons are used to irradiate tissues, such as during FLASH pre-clinical irradiations, the electron beam energy is one of the critical parameters that determine the dose distribution. Moreover, during such irradiations, linear accelerators (linacs) usually operate with significan...

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Autores principales: Berne, Alexander, Petersson, Kristoffer, Tullis, Iain D C, Newman, Robert G, Vojnovic, Borivoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOP Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208618/
https://www.ncbi.nlm.nih.gov/pubmed/33361551
http://dx.doi.org/10.1088/1361-6560/abd672
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author Berne, Alexander
Petersson, Kristoffer
Tullis, Iain D C
Newman, Robert G
Vojnovic, Borivoj
author_facet Berne, Alexander
Petersson, Kristoffer
Tullis, Iain D C
Newman, Robert G
Vojnovic, Borivoj
author_sort Berne, Alexander
collection PubMed
description When relativistic electrons are used to irradiate tissues, such as during FLASH pre-clinical irradiations, the electron beam energy is one of the critical parameters that determine the dose distribution. Moreover, during such irradiations, linear accelerators (linacs) usually operate with significant beam loading, where a small change in the accelerator output current can lead to beam energy reduction. Optimisation of the tuning of the accelerator’s radio frequency system is often required. We describe here a robust, easy-to-use device for non-interceptive monitoring of potential variations in the electron beam energy during every linac macro-pulse of an irradiation run. Our approach monitors the accelerated electron fringe beam using two unbiased aluminium annular charge collection plates, positioned in the beam path and with apertures (5 cm in diameter) for the central beam. These plates are complemented by two thin annular screening plates to eliminate crosstalk and equalise the capacitances of the charge collection plates. The ratio of the charge picked up on the downstream collection plate to the sum of charges picked up on the both plates is sensitive to the beam energy and to changes in the energy spectrum shape. The energy sensitivity range is optimised to the investigated beam by the choice of thickness of the first plate. We present simulation and measurement data using electrons generated by a nominal 6 MeV energy linac as well as information on the design, the practical implementation and the use of this monitor.
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spelling pubmed-82086182021-06-17 Monitoring electron energies during FLASH irradiations Berne, Alexander Petersson, Kristoffer Tullis, Iain D C Newman, Robert G Vojnovic, Borivoj Phys Med Biol Paper When relativistic electrons are used to irradiate tissues, such as during FLASH pre-clinical irradiations, the electron beam energy is one of the critical parameters that determine the dose distribution. Moreover, during such irradiations, linear accelerators (linacs) usually operate with significant beam loading, where a small change in the accelerator output current can lead to beam energy reduction. Optimisation of the tuning of the accelerator’s radio frequency system is often required. We describe here a robust, easy-to-use device for non-interceptive monitoring of potential variations in the electron beam energy during every linac macro-pulse of an irradiation run. Our approach monitors the accelerated electron fringe beam using two unbiased aluminium annular charge collection plates, positioned in the beam path and with apertures (5 cm in diameter) for the central beam. These plates are complemented by two thin annular screening plates to eliminate crosstalk and equalise the capacitances of the charge collection plates. The ratio of the charge picked up on the downstream collection plate to the sum of charges picked up on the both plates is sensitive to the beam energy and to changes in the energy spectrum shape. The energy sensitivity range is optimised to the investigated beam by the choice of thickness of the first plate. We present simulation and measurement data using electrons generated by a nominal 6 MeV energy linac as well as information on the design, the practical implementation and the use of this monitor. IOP Publishing 2021-02-21 2021-02-08 /pmc/articles/PMC8208618/ /pubmed/33361551 http://dx.doi.org/10.1088/1361-6560/abd672 Text en © 2021 Institute of Physics and Engineering in Medicine https://creativecommons.org/licenses/by/4.0/Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence (https://creativecommons.org/licenses/by/4.0/) . Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
spellingShingle Paper
Berne, Alexander
Petersson, Kristoffer
Tullis, Iain D C
Newman, Robert G
Vojnovic, Borivoj
Monitoring electron energies during FLASH irradiations
title Monitoring electron energies during FLASH irradiations
title_full Monitoring electron energies during FLASH irradiations
title_fullStr Monitoring electron energies during FLASH irradiations
title_full_unstemmed Monitoring electron energies during FLASH irradiations
title_short Monitoring electron energies during FLASH irradiations
title_sort monitoring electron energies during flash irradiations
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208618/
https://www.ncbi.nlm.nih.gov/pubmed/33361551
http://dx.doi.org/10.1088/1361-6560/abd672
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