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CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition

Doxorubicin is one of the most frequently used chemotherapy drugs in the treatment of osteosarcoma (OS), but the emergence of chemoresistance often leads to treatment failure. C-X-C motif chemokine receptor 4 (CXCR4) has been demonstrated to regulate OS progression and metastasis. However, whether C...

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Detalles Bibliográficos
Autores principales:	Liao, Yu-Xin, Lv, Ji-Yang, Zhou, Zi-Fei, Xu, Tian-Yang, Yang, Dong, Gao, Qiu-Ming, Fan, Lin, Li, Guo-Dong, Yu, Hai-Yang, Liu, Kai-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208619/ https://www.ncbi.nlm.nih.gov/pubmed/34080667 http://dx.doi.org/10.3892/ijo.2021.5229

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