Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

Infection by highly pathogenic coronaviruses results in substantial apoptosis. However, the physiological relevance of apoptosis in the pathogenesis of coronavirus infections is unknown. Here, with a combination of in vitro, ex vivo, and in vivo models, we demonstrated that protein kinase R–like end...

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Detalles Bibliográficos
Autores principales: Chu, Hin, Shuai, Huiping, Hou, Yuxin, Zhang, Xi, Wen, Lei, Huang, Xiner, Hu, Bingjie, Yang, Dong, Wang, Yixin, Yoon, Chaemin, Wong, Bosco Ho-Yin, Li, Cun, Zhao, Xiaoyu, Poon, Vincent Kwok-Man, Cai, Jian-Piao, Wong, Kenneth Kak-Yuen, Yeung, Man-Lung, Zhou, Jie, Au-Yeung, Rex Kwok-Him, Yuan, Shuofeng, Jin, Dong-Yan, Kok, Kin-Hang, Perlman, Stanley, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208716/
https://www.ncbi.nlm.nih.gov/pubmed/34134991
http://dx.doi.org/10.1126/sciadv.abf8577

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