Cargando…
Burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation
INTRODUCTION: Burkholderia cepacia is an aerobic, Gram-negative bacillus, which exhibits innate resistance to multiple antibiotics and disinfectants. Although it is a chronic colonizer of the respiratory tract, it may rarely present with fatal necrotizing pneumonia-like features in immunosuppressed...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208758/ https://www.ncbi.nlm.nih.gov/pubmed/34151173 http://dx.doi.org/10.1099/acmi.0.000222 |
_version_ | 1783708984801230848 |
---|---|
author | Ibrahim, Sufyan Madigubba, Haritha N, Himanshu Y. Chawla, Kiran |
author_facet | Ibrahim, Sufyan Madigubba, Haritha N, Himanshu Y. Chawla, Kiran |
author_sort | Ibrahim, Sufyan |
collection | PubMed |
description | INTRODUCTION: Burkholderia cepacia is an aerobic, Gram-negative bacillus, which exhibits innate resistance to multiple antibiotics and disinfectants. Although it is a chronic colonizer of the respiratory tract, it may rarely present with fatal necrotizing pneumonia-like features in immunosuppressed individuals, as those with chronic granulomatous disease, or patients with significant pulmonary compromise, like cystic fibrosis. CASE PRESENTATION: A 76-year-old male presented with complaints of breathlessness, cough with mucoid expectoration and fever for 3 days. He had a history of coronary artery disease, chronic obstructive pulmonary disease (COPD), diabetes mellitus and hypertension, under treatment. Pulmonary function tests were suggestive of very severe obstruction (FEV1/FVC was 55 %). So, clinical diagnosis of acute exacerbation of COPD was established. Sputum culture grew B. cepacia . The patient was treated with ceftazidime and meropenem along with inhalational bronchodilators and steroids, and showed symptomatic response to therapy. CONCLUSION: There is paucity of the literature describing B. cepacia as a potential cause for acute exacerbations in relatively common clinical conditions, such as COPD. This case report highlights the speculation of this rare possibility, thereby alerting a clinician dealing with such cases. |
format | Online Article Text |
id | pubmed-8208758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-82087582021-06-17 Burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation Ibrahim, Sufyan Madigubba, Haritha N, Himanshu Y. Chawla, Kiran Access Microbiol Case Reports INTRODUCTION: Burkholderia cepacia is an aerobic, Gram-negative bacillus, which exhibits innate resistance to multiple antibiotics and disinfectants. Although it is a chronic colonizer of the respiratory tract, it may rarely present with fatal necrotizing pneumonia-like features in immunosuppressed individuals, as those with chronic granulomatous disease, or patients with significant pulmonary compromise, like cystic fibrosis. CASE PRESENTATION: A 76-year-old male presented with complaints of breathlessness, cough with mucoid expectoration and fever for 3 days. He had a history of coronary artery disease, chronic obstructive pulmonary disease (COPD), diabetes mellitus and hypertension, under treatment. Pulmonary function tests were suggestive of very severe obstruction (FEV1/FVC was 55 %). So, clinical diagnosis of acute exacerbation of COPD was established. Sputum culture grew B. cepacia . The patient was treated with ceftazidime and meropenem along with inhalational bronchodilators and steroids, and showed symptomatic response to therapy. CONCLUSION: There is paucity of the literature describing B. cepacia as a potential cause for acute exacerbations in relatively common clinical conditions, such as COPD. This case report highlights the speculation of this rare possibility, thereby alerting a clinician dealing with such cases. Microbiology Society 2021-04-15 /pmc/articles/PMC8208758/ /pubmed/34151173 http://dx.doi.org/10.1099/acmi.0.000222 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article. |
spellingShingle | Case Reports Ibrahim, Sufyan Madigubba, Haritha N, Himanshu Y. Chawla, Kiran Burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation |
title |
Burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation |
title_full |
Burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation |
title_fullStr |
Burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation |
title_full_unstemmed |
Burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation |
title_short |
Burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation |
title_sort | burkholderia cepacia infection in a non-cystic fibrosis patient: an arcane presentation |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208758/ https://www.ncbi.nlm.nih.gov/pubmed/34151173 http://dx.doi.org/10.1099/acmi.0.000222 |
work_keys_str_mv | AT ibrahimsufyan burkholderiacepaciainfectioninanoncysticfibrosispatientanarcanepresentation AT madigubbaharitha burkholderiacepaciainfectioninanoncysticfibrosispatientanarcanepresentation AT nhimanshuy burkholderiacepaciainfectioninanoncysticfibrosispatientanarcanepresentation AT chawlakiran burkholderiacepaciainfectioninanoncysticfibrosispatientanarcanepresentation |