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First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent

Current phylogenetic analysis of the flavivirus genus has identified a group of mosquito-borne viruses for which the vertebrate hosts are currently unknown. Here we report the identification of a novel member of this group from a peridomestic rodent species (Sundamys muelleri) collected in Sarawak,...

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Detalles Bibliográficos
Autores principales: Blasdell, Kim R., Wynne, James W., Perera, David, Firth, Cadhla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208762/
https://www.ncbi.nlm.nih.gov/pubmed/34151174
http://dx.doi.org/10.1099/acmi.0.000223
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author Blasdell, Kim R.
Wynne, James W.
Perera, David
Firth, Cadhla
author_facet Blasdell, Kim R.
Wynne, James W.
Perera, David
Firth, Cadhla
author_sort Blasdell, Kim R.
collection PubMed
description Current phylogenetic analysis of the flavivirus genus has identified a group of mosquito-borne viruses for which the vertebrate hosts are currently unknown. Here we report the identification of a novel member of this group from a peridomestic rodent species (Sundamys muelleri) collected in Sarawak, Malaysia in 2016. We propose to name this novel flavivirus Batu Kawa virus after the location in which it was identified, with the abbreviation BKWV. Characterization of the BKWV genome allowed identification of putative mature peptides, potential enzyme motifs and conserved structural elements. Phylogenetic analysis found BKWV to be most closely related to Nhumirim virus (from Brazil) and Barkedji virus (from Senegal and Israel). Both of these viruses have been identified in Culex mosquitoes and belong to a group of viruses with unknown vertebrate hosts. This is the first known report of a member of this group of viruses from a potential mammalian host.
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spelling pubmed-82087622021-06-17 First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent Blasdell, Kim R. Wynne, James W. Perera, David Firth, Cadhla Access Microbiol Research Articles Current phylogenetic analysis of the flavivirus genus has identified a group of mosquito-borne viruses for which the vertebrate hosts are currently unknown. Here we report the identification of a novel member of this group from a peridomestic rodent species (Sundamys muelleri) collected in Sarawak, Malaysia in 2016. We propose to name this novel flavivirus Batu Kawa virus after the location in which it was identified, with the abbreviation BKWV. Characterization of the BKWV genome allowed identification of putative mature peptides, potential enzyme motifs and conserved structural elements. Phylogenetic analysis found BKWV to be most closely related to Nhumirim virus (from Brazil) and Barkedji virus (from Senegal and Israel). Both of these viruses have been identified in Culex mosquitoes and belong to a group of viruses with unknown vertebrate hosts. This is the first known report of a member of this group of viruses from a potential mammalian host. Microbiology Society 2021-04-15 /pmc/articles/PMC8208762/ /pubmed/34151174 http://dx.doi.org/10.1099/acmi.0.000223 Text en © 2021 Not applicable https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
spellingShingle Research Articles
Blasdell, Kim R.
Wynne, James W.
Perera, David
Firth, Cadhla
First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent
title First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent
title_full First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent
title_fullStr First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent
title_full_unstemmed First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent
title_short First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent
title_sort first detection of a novel ‘unknown host’ flavivirus in a malaysian rodent
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208762/
https://www.ncbi.nlm.nih.gov/pubmed/34151174
http://dx.doi.org/10.1099/acmi.0.000223
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