Cargando…
First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent
Current phylogenetic analysis of the flavivirus genus has identified a group of mosquito-borne viruses for which the vertebrate hosts are currently unknown. Here we report the identification of a novel member of this group from a peridomestic rodent species (Sundamys muelleri) collected in Sarawak,...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208762/ https://www.ncbi.nlm.nih.gov/pubmed/34151174 http://dx.doi.org/10.1099/acmi.0.000223 |
_version_ | 1783708985809960960 |
---|---|
author | Blasdell, Kim R. Wynne, James W. Perera, David Firth, Cadhla |
author_facet | Blasdell, Kim R. Wynne, James W. Perera, David Firth, Cadhla |
author_sort | Blasdell, Kim R. |
collection | PubMed |
description | Current phylogenetic analysis of the flavivirus genus has identified a group of mosquito-borne viruses for which the vertebrate hosts are currently unknown. Here we report the identification of a novel member of this group from a peridomestic rodent species (Sundamys muelleri) collected in Sarawak, Malaysia in 2016. We propose to name this novel flavivirus Batu Kawa virus after the location in which it was identified, with the abbreviation BKWV. Characterization of the BKWV genome allowed identification of putative mature peptides, potential enzyme motifs and conserved structural elements. Phylogenetic analysis found BKWV to be most closely related to Nhumirim virus (from Brazil) and Barkedji virus (from Senegal and Israel). Both of these viruses have been identified in Culex mosquitoes and belong to a group of viruses with unknown vertebrate hosts. This is the first known report of a member of this group of viruses from a potential mammalian host. |
format | Online Article Text |
id | pubmed-8208762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-82087622021-06-17 First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent Blasdell, Kim R. Wynne, James W. Perera, David Firth, Cadhla Access Microbiol Research Articles Current phylogenetic analysis of the flavivirus genus has identified a group of mosquito-borne viruses for which the vertebrate hosts are currently unknown. Here we report the identification of a novel member of this group from a peridomestic rodent species (Sundamys muelleri) collected in Sarawak, Malaysia in 2016. We propose to name this novel flavivirus Batu Kawa virus after the location in which it was identified, with the abbreviation BKWV. Characterization of the BKWV genome allowed identification of putative mature peptides, potential enzyme motifs and conserved structural elements. Phylogenetic analysis found BKWV to be most closely related to Nhumirim virus (from Brazil) and Barkedji virus (from Senegal and Israel). Both of these viruses have been identified in Culex mosquitoes and belong to a group of viruses with unknown vertebrate hosts. This is the first known report of a member of this group of viruses from a potential mammalian host. Microbiology Society 2021-04-15 /pmc/articles/PMC8208762/ /pubmed/34151174 http://dx.doi.org/10.1099/acmi.0.000223 Text en © 2021 Not applicable https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution. |
spellingShingle | Research Articles Blasdell, Kim R. Wynne, James W. Perera, David Firth, Cadhla First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent |
title | First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent |
title_full | First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent |
title_fullStr | First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent |
title_full_unstemmed | First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent |
title_short | First detection of a novel ‘unknown host’ flavivirus in a Malaysian rodent |
title_sort | first detection of a novel ‘unknown host’ flavivirus in a malaysian rodent |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208762/ https://www.ncbi.nlm.nih.gov/pubmed/34151174 http://dx.doi.org/10.1099/acmi.0.000223 |
work_keys_str_mv | AT blasdellkimr firstdetectionofanovelunknownhostflavivirusinamalaysianrodent AT wynnejamesw firstdetectionofanovelunknownhostflavivirusinamalaysianrodent AT pereradavid firstdetectionofanovelunknownhostflavivirusinamalaysianrodent AT firthcadhla firstdetectionofanovelunknownhostflavivirusinamalaysianrodent |