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Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population

Few studies have measured the effect of genetic factors on dementia and cognitive decline in healthy older individuals followed prospectively. We studied cumulative incidence of dementia and cognitive decline, stratified by APOE genotypes and polygenic risk score (PRS) tertiles, in 12,978 participan...

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Detalles Bibliográficos
Autores principales:	Riaz, Moeen, Huq, Aamira, Ryan, Joanne, Orchard, Suzanne G, Tiller, Jane, Lockery, Jessica, Woods, Robyn L., Wolfe, Rory, Renton, Alan E., Goate, Alison M., Sebra, Robert, Schadt, Eric, Brodtmann, Amy, Shah, Raj C., Storey, Elsdon, Murray, Anne M, McNeil, John J., Lacaze, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208779/ https://www.ncbi.nlm.nih.gov/pubmed/34041846 http://dx.doi.org/10.1111/acel.13384

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