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circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we...

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Autores principales: Song, Minmin, Zhao, Guangfeng, Sun, Haixiang, Yao, Simin, Zhou, Zhenhua, Jiang, Peipei, Wu, Qianwen, Zhu, Hui, Wang, Huiyan, Dai, Chenyan, Wang, Jingmei, Li, Ruotian, Cao, Yun, Lv, Haining, Liu, Dan, Dai, Jianwu, Zhou, Yan, Hu, Yali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208816/
https://www.ncbi.nlm.nih.gov/pubmed/34132637
http://dx.doi.org/10.7554/eLife.65735
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author Song, Minmin
Zhao, Guangfeng
Sun, Haixiang
Yao, Simin
Zhou, Zhenhua
Jiang, Peipei
Wu, Qianwen
Zhu, Hui
Wang, Huiyan
Dai, Chenyan
Wang, Jingmei
Li, Ruotian
Cao, Yun
Lv, Haining
Liu, Dan
Dai, Jianwu
Zhou, Yan
Hu, Yali
author_facet Song, Minmin
Zhao, Guangfeng
Sun, Haixiang
Yao, Simin
Zhou, Zhenhua
Jiang, Peipei
Wu, Qianwen
Zhu, Hui
Wang, Huiyan
Dai, Chenyan
Wang, Jingmei
Li, Ruotian
Cao, Yun
Lv, Haining
Liu, Dan
Dai, Jianwu
Zhou, Yan
Hu, Yali
author_sort Song, Minmin
collection PubMed
description Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21–5 p to inhibit miR-21–5 p expression and activity, which in turn results in upregulation of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (EEC–EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC–EMT and administration of miR-21–5 p could reverse this process and improve endometrial fibrosis. Our findings revealed that the dysfunction of circPTPN12/miR-21–5 p/∆Np63α pathway contributed to the pathogenesis of endometrial fibrosis.
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spelling pubmed-82088162021-06-21 circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis Song, Minmin Zhao, Guangfeng Sun, Haixiang Yao, Simin Zhou, Zhenhua Jiang, Peipei Wu, Qianwen Zhu, Hui Wang, Huiyan Dai, Chenyan Wang, Jingmei Li, Ruotian Cao, Yun Lv, Haining Liu, Dan Dai, Jianwu Zhou, Yan Hu, Yali eLife Cell Biology Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21–5 p to inhibit miR-21–5 p expression and activity, which in turn results in upregulation of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (EEC–EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC–EMT and administration of miR-21–5 p could reverse this process and improve endometrial fibrosis. Our findings revealed that the dysfunction of circPTPN12/miR-21–5 p/∆Np63α pathway contributed to the pathogenesis of endometrial fibrosis. eLife Sciences Publications, Ltd 2021-06-16 /pmc/articles/PMC8208816/ /pubmed/34132637 http://dx.doi.org/10.7554/eLife.65735 Text en © 2021, Song et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Song, Minmin
Zhao, Guangfeng
Sun, Haixiang
Yao, Simin
Zhou, Zhenhua
Jiang, Peipei
Wu, Qianwen
Zhu, Hui
Wang, Huiyan
Dai, Chenyan
Wang, Jingmei
Li, Ruotian
Cao, Yun
Lv, Haining
Liu, Dan
Dai, Jianwu
Zhou, Yan
Hu, Yali
circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
title circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
title_full circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
title_fullStr circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
title_full_unstemmed circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
title_short circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
title_sort circptpn12/mir-21–5 p/∆np63α pathway contributes to human endometrial fibrosis
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208816/
https://www.ncbi.nlm.nih.gov/pubmed/34132637
http://dx.doi.org/10.7554/eLife.65735
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