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Understanding the evolution of multiple drug resistance in structured populations
The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood. Here, we argue that studying MDR evolution by focusing upon the dynamical equations for linkage disequilibrium (LD) can greatl...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208818/ https://www.ncbi.nlm.nih.gov/pubmed/34061029 http://dx.doi.org/10.7554/eLife.65645 |
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author | McLeod, David V Gandon, Sylvain |
author_facet | McLeod, David V Gandon, Sylvain |
author_sort | McLeod, David V |
collection | PubMed |
description | The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood. Here, we argue that studying MDR evolution by focusing upon the dynamical equations for linkage disequilibrium (LD) can greatly simplify the calculations, generate more insight, and provide a unified framework for understanding the role of population structure. We demonstrate how a general epidemiological model of MDR evolution can be recast in terms of the LD equations. These equations reveal how the different forces generating and propagating LD operate in a dynamical setting at both the population and metapopulation levels. We then apply these insights to show how the LD perspective: (i) explains equilibrium patterns of MDR, (ii) provides a simple interpretative framework for transient evolutionary dynamics, and (iii) can be used to assess the consequences of different drug prescription strategies for MDR evolution. |
format | Online Article Text |
id | pubmed-8208818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-82088182021-06-21 Understanding the evolution of multiple drug resistance in structured populations McLeod, David V Gandon, Sylvain eLife Ecology The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood. Here, we argue that studying MDR evolution by focusing upon the dynamical equations for linkage disequilibrium (LD) can greatly simplify the calculations, generate more insight, and provide a unified framework for understanding the role of population structure. We demonstrate how a general epidemiological model of MDR evolution can be recast in terms of the LD equations. These equations reveal how the different forces generating and propagating LD operate in a dynamical setting at both the population and metapopulation levels. We then apply these insights to show how the LD perspective: (i) explains equilibrium patterns of MDR, (ii) provides a simple interpretative framework for transient evolutionary dynamics, and (iii) can be used to assess the consequences of different drug prescription strategies for MDR evolution. eLife Sciences Publications, Ltd 2021-06-01 /pmc/articles/PMC8208818/ /pubmed/34061029 http://dx.doi.org/10.7554/eLife.65645 Text en © 2021, McLeod and Gandon https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Ecology McLeod, David V Gandon, Sylvain Understanding the evolution of multiple drug resistance in structured populations |
title | Understanding the evolution of multiple drug resistance in structured populations |
title_full | Understanding the evolution of multiple drug resistance in structured populations |
title_fullStr | Understanding the evolution of multiple drug resistance in structured populations |
title_full_unstemmed | Understanding the evolution of multiple drug resistance in structured populations |
title_short | Understanding the evolution of multiple drug resistance in structured populations |
title_sort | understanding the evolution of multiple drug resistance in structured populations |
topic | Ecology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208818/ https://www.ncbi.nlm.nih.gov/pubmed/34061029 http://dx.doi.org/10.7554/eLife.65645 |
work_keys_str_mv | AT mcleoddavidv understandingtheevolutionofmultipledrugresistanceinstructuredpopulations AT gandonsylvain understandingtheevolutionofmultipledrugresistanceinstructuredpopulations |