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Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals

Ever-growing research efforts are demonstrating the potential of medicinal plants and their phytochemicals to prevent and manage obesity, either individually or synergistically. Multiple combinations of phytochemicals can result in a synergistic activity that increases their beneficial effects at mo...

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Autores principales: Saad, Bashar, Ghareeb, Bilal, Kmail, Abdalsalam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208872/
https://www.ncbi.nlm.nih.gov/pubmed/34211580
http://dx.doi.org/10.1155/2021/9995903
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author Saad, Bashar
Ghareeb, Bilal
Kmail, Abdalsalam
author_facet Saad, Bashar
Ghareeb, Bilal
Kmail, Abdalsalam
author_sort Saad, Bashar
collection PubMed
description Ever-growing research efforts are demonstrating the potential of medicinal plants and their phytochemicals to prevent and manage obesity, either individually or synergistically. Multiple combinations of phytochemicals can result in a synergistic activity that increases their beneficial effects at molecular, cellular, metabolic, and temporal levels, offering advantages over chemically synthesized drug-based treatments. Herbs and their derived compounds have the potential for controlling appetite, inhibiting pancreatic lipase activity, stimulating thermogenesis and lipid metabolism, increasing satiety, promoting lipolysis, regulating adipogenesis, and inducing apoptosis in adipocytes. Furthermore, targeting adipocyte life cycle using various dietary bioactives that affect different stages of adipocyte life cycle represents also an important target in the development of new antiobesity drugs. In this regard, different stages of adipocyte development that are targeted by antiobesity drugs can include preadipocytes, maturing preadipocytes, and mature adipocytes. Various herbal-derived active compounds, such as capsaicin, genistein, apigenin, luteolin, kaempferol, myricetin, quercetin, docosahexaenoic acid, quercetin, resveratrol, and ajoene, affect adipocytes during specific stages of development, resulting in either inhibition of adipogenesis or induction of apoptosis. Although numerous molecular targets that can be used for both treatment and prevention of obesity have been identified, targeted single cellular receptor or pathway has resulted in limited success. In this review, we discuss the state-of-the-art knowledge about antiobesity medicinal plants and their active compounds and their effects on several cellular, molecular, and metabolic pathways simultaneously with multiple phytochemicals through synergistic functioning which might be an appropriate approach to better management of obesity. In addition, epigenetic mechanisms (acetylation, methylation, miRNAs, ubiquitylation, phosphorylation, and chromatin packaging) of phytochemicals and their preventive and therapeutic perspective are explored in this review.
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spelling pubmed-82088722021-06-30 Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals Saad, Bashar Ghareeb, Bilal Kmail, Abdalsalam Evid Based Complement Alternat Med Review Article Ever-growing research efforts are demonstrating the potential of medicinal plants and their phytochemicals to prevent and manage obesity, either individually or synergistically. Multiple combinations of phytochemicals can result in a synergistic activity that increases their beneficial effects at molecular, cellular, metabolic, and temporal levels, offering advantages over chemically synthesized drug-based treatments. Herbs and their derived compounds have the potential for controlling appetite, inhibiting pancreatic lipase activity, stimulating thermogenesis and lipid metabolism, increasing satiety, promoting lipolysis, regulating adipogenesis, and inducing apoptosis in adipocytes. Furthermore, targeting adipocyte life cycle using various dietary bioactives that affect different stages of adipocyte life cycle represents also an important target in the development of new antiobesity drugs. In this regard, different stages of adipocyte development that are targeted by antiobesity drugs can include preadipocytes, maturing preadipocytes, and mature adipocytes. Various herbal-derived active compounds, such as capsaicin, genistein, apigenin, luteolin, kaempferol, myricetin, quercetin, docosahexaenoic acid, quercetin, resveratrol, and ajoene, affect adipocytes during specific stages of development, resulting in either inhibition of adipogenesis or induction of apoptosis. Although numerous molecular targets that can be used for both treatment and prevention of obesity have been identified, targeted single cellular receptor or pathway has resulted in limited success. In this review, we discuss the state-of-the-art knowledge about antiobesity medicinal plants and their active compounds and their effects on several cellular, molecular, and metabolic pathways simultaneously with multiple phytochemicals through synergistic functioning which might be an appropriate approach to better management of obesity. In addition, epigenetic mechanisms (acetylation, methylation, miRNAs, ubiquitylation, phosphorylation, and chromatin packaging) of phytochemicals and their preventive and therapeutic perspective are explored in this review. Hindawi 2021-06-09 /pmc/articles/PMC8208872/ /pubmed/34211580 http://dx.doi.org/10.1155/2021/9995903 Text en Copyright © 2021 Bashar Saad et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Saad, Bashar
Ghareeb, Bilal
Kmail, Abdalsalam
Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals
title Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals
title_full Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals
title_fullStr Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals
title_full_unstemmed Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals
title_short Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals
title_sort metabolic and epigenetics action mechanisms of antiobesity medicinal plants and phytochemicals
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208872/
https://www.ncbi.nlm.nih.gov/pubmed/34211580
http://dx.doi.org/10.1155/2021/9995903
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