PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor

In our previous study, we found that inhibition of protein tyrosine phosphatase non-receptor type 3 (PTPN3), which is expressed in lymphocytes, enhances lymphocyte activation, suggesting PTPN3 may act as an immune checkpoint molecule. However, PTPN3 is also expressed in various cancers, and the biol...

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Detalles Bibliográficos
Autores principales: Koga, Satoko, Onishi, Hideya, Masuda, Shogo, Fujimura, Akiko, Ichimiya, Shu, Nakayama, Kazunori, Imaizumi, Akira, Nishiyama, Kenichi, Kojima, Masayuki, Miyoshi, Kei, Nakamura, Katsuya, Umebayashi, Masayo, Morisaki, Takashi, Nakamura, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208899/
https://www.ncbi.nlm.nih.gov/pubmed/34134073
http://dx.doi.org/10.1016/j.tranon.2021.101152

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