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Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery
BACKGROUND AND AIMS: Patients with obesity are at high risk of suffering from arterial and venous peripheral vascular disease (PVD). Bariatric surgery is an effective strategy to achieve weight reduction for patients with obesity. The long-term impact of bariatric surgery on obesity-related morbidit...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208905/ https://www.ncbi.nlm.nih.gov/pubmed/33433660 http://dx.doi.org/10.1007/s00423-020-02066-9 |
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author | Moussa, Osama Ardissino, Maddalena Muttoni, Silvia Faraj, Ara Tang, Alice Khan, Omar Collins, Peter Jaffer, Usman Purkayastha, Sanjay |
author_facet | Moussa, Osama Ardissino, Maddalena Muttoni, Silvia Faraj, Ara Tang, Alice Khan, Omar Collins, Peter Jaffer, Usman Purkayastha, Sanjay |
author_sort | Moussa, Osama |
collection | PubMed |
description | BACKGROUND AND AIMS: Patients with obesity are at high risk of suffering from arterial and venous peripheral vascular disease (PVD). Bariatric surgery is an effective strategy to achieve weight reduction for patients with obesity. The long-term impact of bariatric surgery on obesity-related morbidity is subject to increasing research interest. This study aimed to ascertain the impact of bariatric surgery on the long-term occurrence of PVD in patients with obesity. METHODS: The study population was extracted from the Clinical Practice Research Datalink, a nation-wide database containing primary and secondary care records of consenting patients. The intervention cohort was 2959 patients who had undergone bariatric surgery during follow-up; their controls were 2959 propensity-score-matched counterparts. The primary endpoint was development of any PVD: arterial or venous. Secondary endpoints were incident peripheral arterial disease alone, incident peripheral venous disease alone. RESULTS: Three hundred forty-six patients suffered a primary endpoint during follow-up. Bariatric surgery did not improve peripheral vascular disease rates as a whole, but it was associated with significantly lower event rates of arterial disease (HR = 0.560, 95%CI 0.327–0.959, p = 0.035) but higher event rates of venous disease (HR = 1.685, 95%CI 1.256–2.262, p < 0.001). CONCLUSIONS: Bariatric surgery was associated with significantly reduced long-term occurrence of arterial disease but increased occurrence of venous disease in patients with obesity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00423-020-02066-9. |
format | Online Article Text |
id | pubmed-8208905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-82089052021-07-01 Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery Moussa, Osama Ardissino, Maddalena Muttoni, Silvia Faraj, Ara Tang, Alice Khan, Omar Collins, Peter Jaffer, Usman Purkayastha, Sanjay Langenbecks Arch Surg Original Article BACKGROUND AND AIMS: Patients with obesity are at high risk of suffering from arterial and venous peripheral vascular disease (PVD). Bariatric surgery is an effective strategy to achieve weight reduction for patients with obesity. The long-term impact of bariatric surgery on obesity-related morbidity is subject to increasing research interest. This study aimed to ascertain the impact of bariatric surgery on the long-term occurrence of PVD in patients with obesity. METHODS: The study population was extracted from the Clinical Practice Research Datalink, a nation-wide database containing primary and secondary care records of consenting patients. The intervention cohort was 2959 patients who had undergone bariatric surgery during follow-up; their controls were 2959 propensity-score-matched counterparts. The primary endpoint was development of any PVD: arterial or venous. Secondary endpoints were incident peripheral arterial disease alone, incident peripheral venous disease alone. RESULTS: Three hundred forty-six patients suffered a primary endpoint during follow-up. Bariatric surgery did not improve peripheral vascular disease rates as a whole, but it was associated with significantly lower event rates of arterial disease (HR = 0.560, 95%CI 0.327–0.959, p = 0.035) but higher event rates of venous disease (HR = 1.685, 95%CI 1.256–2.262, p < 0.001). CONCLUSIONS: Bariatric surgery was associated with significantly reduced long-term occurrence of arterial disease but increased occurrence of venous disease in patients with obesity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00423-020-02066-9. Springer Berlin Heidelberg 2021-01-12 2021 /pmc/articles/PMC8208905/ /pubmed/33433660 http://dx.doi.org/10.1007/s00423-020-02066-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Moussa, Osama Ardissino, Maddalena Muttoni, Silvia Faraj, Ara Tang, Alice Khan, Omar Collins, Peter Jaffer, Usman Purkayastha, Sanjay Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery |
title | Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery |
title_full | Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery |
title_fullStr | Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery |
title_full_unstemmed | Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery |
title_short | Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery |
title_sort | long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208905/ https://www.ncbi.nlm.nih.gov/pubmed/33433660 http://dx.doi.org/10.1007/s00423-020-02066-9 |
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