Homing in on genomic instability as a therapeutic target in cancer

While genomic instability is a hallmark of cancer, its genetic vulnerabilities remain poorly understood. Identifying strategies that exploit genomic instability to selectively target cancer cells is a central challenge in cancer biology with major implications for anti-cancer drug development.

Detalles Bibliográficos
Autores principales: Bielski, Craig M., Taylor, Barry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209011/
https://www.ncbi.nlm.nih.gov/pubmed/34135330
http://dx.doi.org/10.1038/s41467-021-23965-5
Descripción
Sumario:While genomic instability is a hallmark of cancer, its genetic vulnerabilities remain poorly understood. Identifying strategies that exploit genomic instability to selectively target cancer cells is a central challenge in cancer biology with major implications for anti-cancer drug development.

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