Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin protomer as a modular subunit to drive oligomerization of antibody fragments and transform antibodies targeting SARS-...

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Detalles Bibliográficos
Autores principales: Rujas, Edurne, Kucharska, Iga, Tan, Yong Zi, Benlekbir, Samir, Cui, Hong, Zhao, Tiantian, Wasney, Gregory A., Budylowski, Patrick, Guvenc, Furkan, Newton, Jocelyn C., Sicard, Taylor, Semesi, Anthony, Muthuraman, Krithika, Nouanesengsy, Amy, Aschner, Clare Burn, Prieto, Katherine, Bueler, Stephanie A., Youssef, Sawsan, Liao-Chan, Sindy, Glanville, Jacob, Christie-Holmes, Natasha, Mubareka, Samira, Gray-Owen, Scott D., Rubinstein, John L., Treanor, Bebhinn, Julien, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209050/
https://www.ncbi.nlm.nih.gov/pubmed/34135340
http://dx.doi.org/10.1038/s41467-021-23825-2

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