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Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients
Secondary bacterial infections are a potentially fatal complication of influenza infection. We aimed to define the impact of secondary bacterial infections on the clinical course and mortality in coronavirus disease 2019 (COVID-19) patients by comparison with influenza patients. COVID-19 (n = 642) a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209102/ https://www.ncbi.nlm.nih.gov/pubmed/34135459 http://dx.doi.org/10.1038/s41598-021-92220-0 |
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author | Shafran, Noa Shafran, Inbal Ben-Zvi, Haim Sofer, Summer Sheena, Liron Krause, Ilan Shlomai, Amir Goldberg, Elad Sklan, Ella H. |
author_facet | Shafran, Noa Shafran, Inbal Ben-Zvi, Haim Sofer, Summer Sheena, Liron Krause, Ilan Shlomai, Amir Goldberg, Elad Sklan, Ella H. |
author_sort | Shafran, Noa |
collection | PubMed |
description | Secondary bacterial infections are a potentially fatal complication of influenza infection. We aimed to define the impact of secondary bacterial infections on the clinical course and mortality in coronavirus disease 2019 (COVID-19) patients by comparison with influenza patients. COVID-19 (n = 642) and influenza (n = 742) patients, admitted to a large tertiary center in Israel and for whom blood or sputum culture had been taken were selected for this study. Bacterial culture results, clinical parameters, and death rates were compared. COVID-19 patients had higher rates of bacterial infections than influenza patients (12.6% vs. 8.7%). Notably, the time from admission to bacterial growth was longer in COVID-19 compared to influenza patients (4 (1–8) vs. 1 (1–3) days). Late infections (> 48 h after admission) with gram-positive bacteria were more common in COVID-19 patients (28% vs. 9.5%). Secondary infection was associated with a higher risk of death in both patient groups 2.7-fold (1.22–5.83) for COVID-19, and 3.09-fold (1.11–7.38) for Influenza). The association with death remained significant upon adjustment to age and clinical parameters in COVID-19 but not in influenza infection. Secondary bacterial infection is a notable complication associated with worse outcomes in COVID-19 than influenza patients. Careful surveillance and prompt antibiotic treatment may benefit selected patients. |
format | Online Article Text |
id | pubmed-8209102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82091022021-06-17 Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients Shafran, Noa Shafran, Inbal Ben-Zvi, Haim Sofer, Summer Sheena, Liron Krause, Ilan Shlomai, Amir Goldberg, Elad Sklan, Ella H. Sci Rep Article Secondary bacterial infections are a potentially fatal complication of influenza infection. We aimed to define the impact of secondary bacterial infections on the clinical course and mortality in coronavirus disease 2019 (COVID-19) patients by comparison with influenza patients. COVID-19 (n = 642) and influenza (n = 742) patients, admitted to a large tertiary center in Israel and for whom blood or sputum culture had been taken were selected for this study. Bacterial culture results, clinical parameters, and death rates were compared. COVID-19 patients had higher rates of bacterial infections than influenza patients (12.6% vs. 8.7%). Notably, the time from admission to bacterial growth was longer in COVID-19 compared to influenza patients (4 (1–8) vs. 1 (1–3) days). Late infections (> 48 h after admission) with gram-positive bacteria were more common in COVID-19 patients (28% vs. 9.5%). Secondary infection was associated with a higher risk of death in both patient groups 2.7-fold (1.22–5.83) for COVID-19, and 3.09-fold (1.11–7.38) for Influenza). The association with death remained significant upon adjustment to age and clinical parameters in COVID-19 but not in influenza infection. Secondary bacterial infection is a notable complication associated with worse outcomes in COVID-19 than influenza patients. Careful surveillance and prompt antibiotic treatment may benefit selected patients. Nature Publishing Group UK 2021-06-16 /pmc/articles/PMC8209102/ /pubmed/34135459 http://dx.doi.org/10.1038/s41598-021-92220-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Shafran, Noa Shafran, Inbal Ben-Zvi, Haim Sofer, Summer Sheena, Liron Krause, Ilan Shlomai, Amir Goldberg, Elad Sklan, Ella H. Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients |
title | Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients |
title_full | Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients |
title_fullStr | Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients |
title_full_unstemmed | Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients |
title_short | Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients |
title_sort | secondary bacterial infection in covid-19 patients is a stronger predictor for death compared to influenza patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209102/ https://www.ncbi.nlm.nih.gov/pubmed/34135459 http://dx.doi.org/10.1038/s41598-021-92220-0 |
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