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The long lives of primates and the ‘invariant rate of ageing’ hypothesis
Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the ‘invariant rate of ageing’ hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. W...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209124/ https://www.ncbi.nlm.nih.gov/pubmed/34135334 http://dx.doi.org/10.1038/s41467-021-23894-3 |
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| author | Colchero, Fernando Aburto, José Manuel Archie, Elizabeth A. Boesch, Christophe Breuer, Thomas Campos, Fernando A. Collins, Anthony Conde, Dalia A. Cords, Marina Crockford, Catherine Thompson, Melissa Emery Fedigan, Linda M. Fichtel, Claudia Groenenberg, Milou Hobaiter, Catherine Kappeler, Peter M. Lawler, Richard R. Lewis, Rebecca J. Machanda, Zarin P. Manguette, Marie L. Muller, Martin N. Packer, Craig Parnell, Richard J. Perry, Susan Pusey, Anne E. Robbins, Martha M. Seyfarth, Robert M. Silk, Joan B. Staerk, Johanna Stoinski, Tara S. Stokes, Emma J. Strier, Karen B. Strum, Shirley C. Tung, Jenny Villavicencio, Francisco Wittig, Roman M. Wrangham, Richard W. Zuberbühler, Klaus Vaupel, James W. Alberts, Susan C. |
| author_facet | Colchero, Fernando Aburto, José Manuel Archie, Elizabeth A. Boesch, Christophe Breuer, Thomas Campos, Fernando A. Collins, Anthony Conde, Dalia A. Cords, Marina Crockford, Catherine Thompson, Melissa Emery Fedigan, Linda M. Fichtel, Claudia Groenenberg, Milou Hobaiter, Catherine Kappeler, Peter M. Lawler, Richard R. Lewis, Rebecca J. Machanda, Zarin P. Manguette, Marie L. Muller, Martin N. Packer, Craig Parnell, Richard J. Perry, Susan Pusey, Anne E. Robbins, Martha M. Seyfarth, Robert M. Silk, Joan B. Staerk, Johanna Stoinski, Tara S. Stokes, Emma J. Strier, Karen B. Strum, Shirley C. Tung, Jenny Villavicencio, Francisco Wittig, Roman M. Wrangham, Richard W. Zuberbühler, Klaus Vaupel, James W. Alberts, Susan C. |
| author_sort | Colchero, Fernando |
| collection | PubMed |
| description | Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the ‘invariant rate of ageing’ hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality. Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns. Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed. |
| format | Online Article Text |
| id | pubmed-8209124 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82091242021-07-01 The long lives of primates and the ‘invariant rate of ageing’ hypothesis Colchero, Fernando Aburto, José Manuel Archie, Elizabeth A. Boesch, Christophe Breuer, Thomas Campos, Fernando A. Collins, Anthony Conde, Dalia A. Cords, Marina Crockford, Catherine Thompson, Melissa Emery Fedigan, Linda M. Fichtel, Claudia Groenenberg, Milou Hobaiter, Catherine Kappeler, Peter M. Lawler, Richard R. Lewis, Rebecca J. Machanda, Zarin P. Manguette, Marie L. Muller, Martin N. Packer, Craig Parnell, Richard J. Perry, Susan Pusey, Anne E. Robbins, Martha M. Seyfarth, Robert M. Silk, Joan B. Staerk, Johanna Stoinski, Tara S. Stokes, Emma J. Strier, Karen B. Strum, Shirley C. Tung, Jenny Villavicencio, Francisco Wittig, Roman M. Wrangham, Richard W. Zuberbühler, Klaus Vaupel, James W. Alberts, Susan C. Nat Commun Article Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the ‘invariant rate of ageing’ hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality. Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns. Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed. Nature Publishing Group UK 2021-06-16 /pmc/articles/PMC8209124/ /pubmed/34135334 http://dx.doi.org/10.1038/s41467-021-23894-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Colchero, Fernando Aburto, José Manuel Archie, Elizabeth A. Boesch, Christophe Breuer, Thomas Campos, Fernando A. Collins, Anthony Conde, Dalia A. Cords, Marina Crockford, Catherine Thompson, Melissa Emery Fedigan, Linda M. Fichtel, Claudia Groenenberg, Milou Hobaiter, Catherine Kappeler, Peter M. Lawler, Richard R. Lewis, Rebecca J. Machanda, Zarin P. Manguette, Marie L. Muller, Martin N. Packer, Craig Parnell, Richard J. Perry, Susan Pusey, Anne E. Robbins, Martha M. Seyfarth, Robert M. Silk, Joan B. Staerk, Johanna Stoinski, Tara S. Stokes, Emma J. Strier, Karen B. Strum, Shirley C. Tung, Jenny Villavicencio, Francisco Wittig, Roman M. Wrangham, Richard W. Zuberbühler, Klaus Vaupel, James W. Alberts, Susan C. The long lives of primates and the ‘invariant rate of ageing’ hypothesis |
| title | The long lives of primates and the ‘invariant rate of ageing’ hypothesis |
| title_full | The long lives of primates and the ‘invariant rate of ageing’ hypothesis |
| title_fullStr | The long lives of primates and the ‘invariant rate of ageing’ hypothesis |
| title_full_unstemmed | The long lives of primates and the ‘invariant rate of ageing’ hypothesis |
| title_short | The long lives of primates and the ‘invariant rate of ageing’ hypothesis |
| title_sort | long lives of primates and the ‘invariant rate of ageing’ hypothesis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209124/ https://www.ncbi.nlm.nih.gov/pubmed/34135334 http://dx.doi.org/10.1038/s41467-021-23894-3 |
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