Cargando…
Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography
Alzheimer's disease (AD) pathology is frequently observed as a comorbidity in people with dementia with Lewy bodies (DLB). Here, we evaluated the in vivo distribution of tau burden and its influence on the clinical phenotype of DLB. Tau deposition was quantified using [(18)F]-AV1451 positron em...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209140/ https://www.ncbi.nlm.nih.gov/pubmed/33631469 http://dx.doi.org/10.1016/j.neurobiolaging.2020.11.006 |
_version_ | 1783709064473083904 |
---|---|
author | Mak, Elijah Nicastro, Nicolas Malpetti, Maura Savulich, George Surendranathan, Ajenthan Holland, Negin Passamonti, Luca Jones, P Simon Carter, Stephen F. Su, Li Hong, Young T. Fryer, Tim D. Williams, Guy B. Aigbirhio, Franklin Rowe, James B. O'Brien, John T. |
author_facet | Mak, Elijah Nicastro, Nicolas Malpetti, Maura Savulich, George Surendranathan, Ajenthan Holland, Negin Passamonti, Luca Jones, P Simon Carter, Stephen F. Su, Li Hong, Young T. Fryer, Tim D. Williams, Guy B. Aigbirhio, Franklin Rowe, James B. O'Brien, John T. |
author_sort | Mak, Elijah |
collection | PubMed |
description | Alzheimer's disease (AD) pathology is frequently observed as a comorbidity in people with dementia with Lewy bodies (DLB). Here, we evaluated the in vivo distribution of tau burden and its influence on the clinical phenotype of DLB. Tau deposition was quantified using [(18)F]-AV1451 positron emission tomography in people with DLB (n = 10), AD (n = 27), and healthy controls (n = 14). A subset of patients with Lewy body diseases (n = 4) also underwent [(11)C]-PK11195 positron emission tomography to estimate microglial activation. [(18)F]-AV1451 BP(ND) was lower in DLB than AD across widespread regions. The medial temporal lobe [(18)F]-AV1451 BP(ND) distinguished people with DLB from AD (AUC = 0.87), and negatively correlated with Addenbrooke's Cognitive Examination-Revised and Mini-Mental State Examination. There was a high degree of colocalization between [(18)F]-AV1451 and [(11)C]-PK11195 binding (p < 0.001). Our findings of minimal tau burden in DLB confirm previous studies. Nevertheless, the associations of [(18)F]-AV1451 binding with cognitive impairment suggest that tau may interact synergistically with other pathologic processes to aggravate disease severity in DLB. |
format | Online Article Text |
id | pubmed-8209140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82091402021-06-25 Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography Mak, Elijah Nicastro, Nicolas Malpetti, Maura Savulich, George Surendranathan, Ajenthan Holland, Negin Passamonti, Luca Jones, P Simon Carter, Stephen F. Su, Li Hong, Young T. Fryer, Tim D. Williams, Guy B. Aigbirhio, Franklin Rowe, James B. O'Brien, John T. Neurobiol Aging Regular Article Alzheimer's disease (AD) pathology is frequently observed as a comorbidity in people with dementia with Lewy bodies (DLB). Here, we evaluated the in vivo distribution of tau burden and its influence on the clinical phenotype of DLB. Tau deposition was quantified using [(18)F]-AV1451 positron emission tomography in people with DLB (n = 10), AD (n = 27), and healthy controls (n = 14). A subset of patients with Lewy body diseases (n = 4) also underwent [(11)C]-PK11195 positron emission tomography to estimate microglial activation. [(18)F]-AV1451 BP(ND) was lower in DLB than AD across widespread regions. The medial temporal lobe [(18)F]-AV1451 BP(ND) distinguished people with DLB from AD (AUC = 0.87), and negatively correlated with Addenbrooke's Cognitive Examination-Revised and Mini-Mental State Examination. There was a high degree of colocalization between [(18)F]-AV1451 and [(11)C]-PK11195 binding (p < 0.001). Our findings of minimal tau burden in DLB confirm previous studies. Nevertheless, the associations of [(18)F]-AV1451 binding with cognitive impairment suggest that tau may interact synergistically with other pathologic processes to aggravate disease severity in DLB. Elsevier 2021-05 /pmc/articles/PMC8209140/ /pubmed/33631469 http://dx.doi.org/10.1016/j.neurobiolaging.2020.11.006 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Regular Article Mak, Elijah Nicastro, Nicolas Malpetti, Maura Savulich, George Surendranathan, Ajenthan Holland, Negin Passamonti, Luca Jones, P Simon Carter, Stephen F. Su, Li Hong, Young T. Fryer, Tim D. Williams, Guy B. Aigbirhio, Franklin Rowe, James B. O'Brien, John T. Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography |
title | Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography |
title_full | Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography |
title_fullStr | Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography |
title_full_unstemmed | Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography |
title_short | Imaging tau burden in dementia with Lewy bodies using [(18)F]-AV1451 positron emission tomography |
title_sort | imaging tau burden in dementia with lewy bodies using [(18)f]-av1451 positron emission tomography |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209140/ https://www.ncbi.nlm.nih.gov/pubmed/33631469 http://dx.doi.org/10.1016/j.neurobiolaging.2020.11.006 |
work_keys_str_mv | AT makelijah imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT nicastronicolas imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT malpettimaura imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT savulichgeorge imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT surendranathanajenthan imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT hollandnegin imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT passamontiluca imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT jonespsimon imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT carterstephenf imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT suli imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT hongyoungt imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT fryertimd imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT williamsguyb imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT aigbirhiofranklin imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT rowejamesb imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography AT obrienjohnt imagingtauburdenindementiawithlewybodiesusing18fav1451positronemissiontomography |