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CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin

Limited therapeutic options are available for advanced colorectal cancer (CRC). Herein, we report that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, nortopsentin 234 (NORA234), leads to an initial reduction of proliferative and clonogenic potential of CRC sphere cells (CR-CSphCs)...

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Detalles Bibliográficos
Autores principales:	Di Franco, Simone, Parrino, Barbara, Gaggianesi, Miriam, Pantina, Vincenzo Davide, Bianca, Paola, Nicotra, Annalisa, Mangiapane, Laura Rosa, Lo Iacono, Melania, Ganduscio, Gloria, Veschi, Veronica, Brancato, Ornella Roberta, Glaviano, Antonino, Turdo, Alice, Pillitteri, Irene, Colarossi, Lorenzo, Cascioferro, Stella, Carbone, Daniela, Pecoraro, Camilla, Fiori, Micol Eleonora, De Maria, Ruggero, Todaro, Matilde, Screpanti, Isabella, Cirrincione, Girolamo, Diana, Patrizia, Stassi, Giorgio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209271/ https://www.ncbi.nlm.nih.gov/pubmed/34169240 http://dx.doi.org/10.1016/j.isci.2021.102664

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