Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy

S-adenosylhomocysteine (SAH) is hydrolyzed by SAH hydrolase (SAHH) to homocysteine and adenosine. Increased plasma SAH levels were associated with disturbed renal function in patients with diabetes. However, the role and mechanism of SAHH in diabetic nephropathy is still unknown. In the present stud...

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Detalles Bibliográficos
Autores principales: Dai, Xin, Liao, Ruyi, Liu, Chaoqun, Liu, Si, Huang, Haiyan, Liu, Jianjun, Jin, Tianru, Guo, Honghui, Zheng, Zhihua, Xia, Min, Ling, Wenhua, Xiao, Yunjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209273/
https://www.ncbi.nlm.nih.gov/pubmed/34119876
http://dx.doi.org/10.1016/j.redox.2021.102033

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