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Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and distinct biological features compared with other well-known programmed cell death. Ferroptosis can be triggered by many causes including decreased expression of glutathione (GSH), inhibition of the function o...

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Autores principales: Zhang, Yongfa, Lu, Xiaoyang, Tai, Bai, Li, Weijia, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209298/
https://www.ncbi.nlm.nih.gov/pubmed/34149358
http://dx.doi.org/10.3389/fncel.2021.615372
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author Zhang, Yongfa
Lu, Xiaoyang
Tai, Bai
Li, Weijia
Li, Tao
author_facet Zhang, Yongfa
Lu, Xiaoyang
Tai, Bai
Li, Weijia
Li, Tao
author_sort Zhang, Yongfa
collection PubMed
description Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and distinct biological features compared with other well-known programmed cell death. Ferroptosis can be triggered by many causes including decreased expression of glutathione (GSH), inhibition of the function of glutathione-dependent peroxidase 4 (GPX4), and system x(c)(–), all of which finally lead to the over-accumulation of lipid peroxides in the cell. Ferroptosis has been reported to play an important role in the pathophysiological process of various cancers. In recent years, much evidence also proved that ferroptosis is involved in the progress of cerebral stroke. In this review, we summarized the characteristics of ferroptosis and the potential relationship between ferroptosis and ischemic and hemorrhagic stroke, to provide new targets and ideas for the therapy of stroke.
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spelling pubmed-82092982021-06-18 Ferroptosis and Its Multifaceted Roles in Cerebral Stroke Zhang, Yongfa Lu, Xiaoyang Tai, Bai Li, Weijia Li, Tao Front Cell Neurosci Neuroscience Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and distinct biological features compared with other well-known programmed cell death. Ferroptosis can be triggered by many causes including decreased expression of glutathione (GSH), inhibition of the function of glutathione-dependent peroxidase 4 (GPX4), and system x(c)(–), all of which finally lead to the over-accumulation of lipid peroxides in the cell. Ferroptosis has been reported to play an important role in the pathophysiological process of various cancers. In recent years, much evidence also proved that ferroptosis is involved in the progress of cerebral stroke. In this review, we summarized the characteristics of ferroptosis and the potential relationship between ferroptosis and ischemic and hemorrhagic stroke, to provide new targets and ideas for the therapy of stroke. Frontiers Media S.A. 2021-06-03 /pmc/articles/PMC8209298/ /pubmed/34149358 http://dx.doi.org/10.3389/fncel.2021.615372 Text en Copyright © 2021 Zhang, Lu, Tai, Li and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Yongfa
Lu, Xiaoyang
Tai, Bai
Li, Weijia
Li, Tao
Ferroptosis and Its Multifaceted Roles in Cerebral Stroke
title Ferroptosis and Its Multifaceted Roles in Cerebral Stroke
title_full Ferroptosis and Its Multifaceted Roles in Cerebral Stroke
title_fullStr Ferroptosis and Its Multifaceted Roles in Cerebral Stroke
title_full_unstemmed Ferroptosis and Its Multifaceted Roles in Cerebral Stroke
title_short Ferroptosis and Its Multifaceted Roles in Cerebral Stroke
title_sort ferroptosis and its multifaceted roles in cerebral stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209298/
https://www.ncbi.nlm.nih.gov/pubmed/34149358
http://dx.doi.org/10.3389/fncel.2021.615372
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