Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Ding, GangYi, Yang, QiNan, Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209341/
https://www.ncbi.nlm.nih.gov/pubmed/34179308
http://dx.doi.org/10.1016/j.gendis.2020.03.003
_version_ 1783709108111671296
author Yao, Ding
GangYi, Yang
QiNan, Wu
author_facet Yao, Ding
GangYi, Yang
QiNan, Wu
author_sort Yao, Ding
collection PubMed
description Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots.
format Online
Article
Text
id pubmed-8209341
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Chongqing Medical University
record_format MEDLINE/PubMed
spelling pubmed-82093412021-06-25 Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword Yao, Ding GangYi, Yang QiNan, Wu Genes Dis Review Article Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots. Chongqing Medical University 2020-03-19 /pmc/articles/PMC8209341/ /pubmed/34179308 http://dx.doi.org/10.1016/j.gendis.2020.03.003 Text en © 2020 Chongqing Medical University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Yao, Ding
GangYi, Yang
QiNan, Wu
Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword
title Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword
title_full Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword
title_fullStr Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword
title_full_unstemmed Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword
title_short Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword
title_sort autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209341/
https://www.ncbi.nlm.nih.gov/pubmed/34179308
http://dx.doi.org/10.1016/j.gendis.2020.03.003
work_keys_str_mv AT yaoding autophagicdysfunctionofbcelldysfunctionintype2diabetesadoubleedgedsword
AT gangyiyang autophagicdysfunctionofbcelldysfunctionintype2diabetesadoubleedgedsword
AT qinanwu autophagicdysfunctionofbcelldysfunctionintype2diabetesadoubleedgedsword

Ejemplares similares