Cargando…

MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats

Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the quality of life of patients. OA has been established as a disease with metabolic disorder. Cholesterol 25-hydroxylase (CH25H) was proved to play a key role in cartilage cholesterol metabolism. However, the biol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiaochen, Zhang, Li, Shi, Xiaoqing, Liao, Taiyang, Zhang, Nongshan, Gao, Yifan, Xing, Runlin, Wang, Peimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209416/ https://www.ncbi.nlm.nih.gov/pubmed/34149433 http://dx.doi.org/10.3389/fphar.2021.690181

Ejemplares similares

Inhibition of Synovial Macrophage Pyroptosis Alleviates Synovitis and Fibrosis in Knee Osteoarthritis
por: Zhang, Li, et al.
Publicado: (2019)

Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Simiao Powder on Knee Osteoarthritis
por: Huang, Zhengquan, et al.
Publicado: (2020)

Agnuside Alleviates Synovitis and Fibrosis in Knee Osteoarthritis through the Inhibition of HIF-1α and NLRP3 Inflammasome
por: Zhang, Li, et al.
Publicado: (2021)

GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction
por: Ma, Zhenyuan, et al.
Publicado: (2022)

Sanse Powder Essential Oil Nanoemulsion Negatively Regulates TRPA1 by AMPK/mTOR Signaling in Synovitis: Knee Osteoarthritis Rat Model and Fibroblast-Like Synoviocyte Isolates
por: Li, Mingchao, et al.
Publicado: (2021)

Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis
por: Zhang, Li, et al.
Publicado: (2019)

Characteristics of sensory innervation in synovium of rats within different knee osteoarthritis models and the correlation between synovial fibrosis and hyperalgesia
por: Zhang, Li, et al.
Publicado: (2021)

Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4
por: Cao, Chenxi, et al.
Publicado: (2022)

Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine
por: Zhang, Nongshan, et al.
Publicado: (2017)

Vanillic Acid Reduces Pain-Related Behavior in Knee Osteoarthritis Rats Through the Inhibition of NLRP3 Inflammasome-Related Synovitis
por: Ma, Zhenyuan, et al.
Publicado: (2021)

Synovial Fibrosis Involvement in Osteoarthritis
por: Zhang, Li, et al.
Publicado: (2021)

Should synovectomy be performed during total knee arthroplasty for knee osteoarthritis: A protocol for systematic review and meta-analysis
por: Li, Mingchao, et al.
Publicado: (2021)

Interventional Efects of the Topical of “Sanse Powder” Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis
por: Liu, Zixiu, et al.
Publicado: (2021)

Chrysin ameliorates synovitis and fibrosis of osteoarthritic fibroblast-like synoviocytes in rats through PERK/TXNIP/NLRP3 signaling
por: Ding, Liang, et al.
Publicado: (2023)

Interventional effects of the direct application of “Sanse powder” on knee osteoarthritis in rats as determined from lipidomics via UPLC-Q-Exactive Orbitrap MS
por: Wu, Peng, et al.
Publicado: (2020)

Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Radix Achyranthis Bidentatae on Osteoarthritis
por: Zhang, Laigen, et al.
Publicado: (2020)

Ch25h and 25-HC prevent liver steatosis through regulation of cholesterol metabolism and inflammation: Anti-NAFLD role of Ch25h and 25-HC
por: Wang, Yaqiong, et al.
Publicado: (2022)

Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H)
por: Holmes, Roger S., et al.
Publicado: (2011)

New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis
por: Lv, Xiaoman, et al.
Publicado: (2022)

l-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway
por: Liao, Taiyang, et al.
Publicado: (2023)

Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes
por: Jiang, Jieyun, et al.
Publicado: (2023)

Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway
por: Liang, Tongzhou, et al.
Publicado: (2021)

Cartilage Degeneration and Alignment in Severe Varus Knee Osteoarthritis
por: Nakagawa, Yasuaki, et al.
Publicado: (2015)

Tetrahydrohyperforin prevents articular cartilage degeneration and affects autophagy in rats with osteoarthritis
por: Zhang, Jinling, et al.
Publicado: (2018)

Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration
por: Cao, Kun, et al.
Publicado: (2014)

Intraarticular Ligament Degeneration Is Interrelated with Cartilage and Bone Destruction in Osteoarthritis
por: Schulze-Tanzil, Gundula
Publicado: (2019)

Role of Syndecan-4 in the Inhibition of Articular Cartilage Degeneration in Osteoarthritis
por: Hattori, Yoshio, et al.
Publicado: (2023)

Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis
por: Zhang, Haosheng, et al.
Publicado: (2021)

Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior
por: Li, Hui, et al.
Publicado: (2020)

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
por: Feng, Xiaofeng, et al.
Publicado: (2020)

Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes
por: Russo, Lucia, et al.
Publicado: (2020)

Early osteoarthritis after slipped capital femoral epiphysis: Cartilage degeneration, residual deformity and patient-reported outcome in 25 patients
por: Helgesson, Lukas, et al.
Publicado: (2018)

Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats
por: Gao, Hui, et al.
Publicado: (2020)

Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)
por: Yudoh, Kazuo, et al.
Publicado: (2010)

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis
por: Shin, Hyo Jung, et al.
Publicado: (2019)

Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
por: Ji, Quanbo, et al.
Publicado: (2019)

Trimanganese Tetroxide Nanozyme protects Cartilage against Degeneration by Reducing Oxidative Stress in Osteoarthritis
por: Wang, Wenhan, et al.
Publicado: (2023)

Acupuncture Delays Cartilage Degeneration through Upregulating SIRT1 Expression in Rats with Osteoarthritis
por: Liu, Hui, et al.
Publicado: (2021)

JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy
por: Lin, Zhiming, et al.
Publicado: (2021)

Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection
por: Cho, Soo Jung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0bkgr4518ou5p4gq5g8e9mgv2q