Cargando…

Axotomy Induces Drp1-Dependent Fragmentation of Axonal Mitochondria

It is well established that CNS axons fail to regenerate, undergo retrograde dieback, and form dystrophic growth cones due to both intrinsic and extrinsic factors. We sought to investigate the role of axonal mitochondria in the axonal response to injury. A viral vector (AAV) containing a mitochondri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kedra, Joseph, Lin, Shen, Pacheco, Almudena, Gallo, Gianluca, Smith, George M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209475/ https://www.ncbi.nlm.nih.gov/pubmed/34149354 http://dx.doi.org/10.3389/fnmol.2021.668670

Ejemplares similares

Neurotrophins induce fission of mitochondria along embryonic sensory axons
por: Armijo-Weingart, Lorena, et al.
Publicado: (2019)

SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
por: Ketschek, Andrea, et al.
Publicado: (2022)

LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons
por: Pandey, Jai P., et al.
Publicado: (2022)

Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C. elegans
por: Williams, Wes, et al.
Publicado: (2011)

Unraveling Axon Guidance during Axotomy and Regeneration
por: Domínguez-Romero, Miguel E., et al.
Publicado: (2021)

Unique Axon-to-Soma Signaling Pathways Mediate Dendritic Spine Loss and Hyper-Excitability Post-axotomy
por: Nagendran, Tharkika, et al.
Publicado: (2019)

Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons
por: Sainath, Rajiv, et al.
Publicado: (2021)

In vivo Laser Axotomy in C. elegans
por: Byrne, Alexandra B., et al.
Publicado: (2011)

Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS
por: Gershoni-Emek, Noga, et al.
Publicado: (2018)

Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease?
por: Sbai, Oualid, et al.
Publicado: (2023)

Linking axon transport to regeneration using in vitro laser axotomy
por: Nieuwenhuis, Bart, et al.
Publicado: (2018)

Early alterations in the electrophysiological properties of rat spinal motoneurones following neonatal axotomy
por: Mentis, George Z, et al.
Publicado: (2007)

Drp1 and RB interaction to mediate mitochondria-dependent necroptosis induced by cadmium in hepatocytes
por: Zhang, Shili, et al.
Publicado: (2019)

Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
por: Alam, Tanimul, et al.
Publicado: (2016)

Glycogen synthase kinase 3: a crucial regulator of axotomy-induced axon regeneration
por: Liu, Jinlian, et al.
Publicado: (2019)

Synaptic Plasticity on Motoneurons After Axotomy: A Necessary Change in Paradigm
por: Alvarez, Francisco J., et al.
Publicado: (2020)

Drp1‐dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia
por: Johnson, Joseph, et al.
Publicado: (2021)

Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy
por: Ziegenfuss, Jennifer S., et al.
Publicado: (2012)

Glycolytic System in Axons Supplement Decreased ATP Levels after Axotomy of the Peripheral Nerve
por: Takenaka, Tomofumi, et al.
Publicado: (2023)

Enhanced Immune Response in Immunodeficient Mice Improves Peripheral Nerve Regeneration Following Axotomy
por: Bombeiro, André L., et al.
Publicado: (2016)

Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons
por: Strickland, Iain T., et al.
Publicado: (2011)

Advances in the study of axon–associated vesicles
por: Liu, Yanling, et al.
Publicado: (2022)

Editorial: Axonal growth in normal and pathological conditions
por: Omura, Takao
Publicado: (2022)

Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy
por: Wang, Zheng, et al.
Publicado: (2022)

Systemic and Intravitreal Antagonism of the TNFR1 Signaling Pathway Delays Axotomy-Induced Retinal Ganglion Cell Loss
por: Lucas-Ruiz, Fernando, et al.
Publicado: (2019)

Editorial: Mitochondria as a hub for neurodegenerative disorders
por: Kohler, Verena, et al.
Publicado: (2023)

The Fine Tuning of Drp1-Dependent Mitochondrial Remodeling and Autophagy Controls Neuronal Differentiation
por: Vantaggiato, Chiara, et al.
Publicado: (2019)

Editorial: Pathways and Processes Underpinning Axonal Biology and Pathobiology
por: Sahoo, Pabitra K., et al.
Publicado: (2022)

Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?
por: Rodemer, William, et al.
Publicado: (2020)

Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity
por: Xu, S, et al.
Publicado: (2013)

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff
por: Yu, Rong, et al.
Publicado: (2017)

Spinal cord injury regulates circular RNA expression in axons
por: Siddiq, Mustafa M., et al.
Publicado: (2023)

The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond
por: Lee, Kyu-Sun, et al.
Publicado: (2014)

Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons
por: Wali, Gautam, et al.
Publicado: (2020)

Mitochondrial Reactive Oxygen Species Mediate Activation of TRPV1 and Calcium Entry Following Peripheral Sensory Axotomy
por: Kievit, Bradley, et al.
Publicado: (2022)

Streptozotocin Induces Alzheimer’s Disease-Like Pathology in Hippocampal Neuronal Cells via CDK5/Drp1-Mediated Mitochondrial Fragmentation
por: Park, Junghyung, et al.
Publicado: (2020)

Paclitaxel effects on axonal localization and vesicular trafficking of Na(V)1.8
por: Baker, Christopher A., et al.
Publicado: (2023)

Deletion of CD38 and supplementation of NAD(+) attenuate axon degeneration in a mouse facial nerve axotomy model
por: Takaso, Yuji, et al.
Publicado: (2020)

Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
por: Heo, Keunjung, et al.
Publicado: (2022)

Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination
por: Wilkison, Samantha J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qfbjce6tt5g0j1d0h0ek9qtatm