PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1(ΔHBS) in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling

Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN). In the present study, we showed that treatment with an FGF...

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Detalles Bibliográficos
Autores principales: Wang, Dezhong, Zhao, Tianyang, Zhao, Yushuo, Yin, Yuan, Huang, Yuli, Cheng, Zizhao, Wang, Beibei, Liu, Sidan, Pan, Minling, Sun, Difei, Wang, Zengshou, Zhu, Guanghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209477/
https://www.ncbi.nlm.nih.gov/pubmed/34149434
http://dx.doi.org/10.3389/fphar.2021.690535

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