Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers

RUNX proteins have been shown to behave as “double-edge sword” in wide variety of cancers. Discovery of non-coding RNAs has played linchpin role in improving our understanding about the post-transcriptional regulation of different cell signaling pathways. Several new mechanistic insights and distinc...

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Autores principales: Farooqi, Ammad Ahmad, Gulnara, Kapanova, Mukhanbetzhanovna, Auyezova Ardak, Datkhayev, Ubaidilla, Kussainov, Abay Z., Adylova, Aima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209647/
https://www.ncbi.nlm.nih.gov/pubmed/34189363
http://dx.doi.org/10.1016/j.ncrna.2021.05.001
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author Farooqi, Ammad Ahmad
Gulnara, Kapanova
Mukhanbetzhanovna, Auyezova Ardak
Datkhayev, Ubaidilla
Kussainov, Abay Z.
Adylova, Aima
author_facet Farooqi, Ammad Ahmad
Gulnara, Kapanova
Mukhanbetzhanovna, Auyezova Ardak
Datkhayev, Ubaidilla
Kussainov, Abay Z.
Adylova, Aima
author_sort Farooqi, Ammad Ahmad
collection PubMed
description RUNX proteins have been shown to behave as “double-edge sword” in wide variety of cancers. Discovery of non-coding RNAs has played linchpin role in improving our understanding about the post-transcriptional regulation of different cell signaling pathways. Several new mechanistic insights and distinct modes of cross-regulation of RUNX proteins and non-coding RNAs have been highlighted by recent research. In this review we have attempted to provide an intricate interplay between non-coding RNAs and RUNX proteins in different cancers. Better conceptual and mechanistic understanding of layered regulation of RUNX proteins by non-coding RNAs will be helpful in effective translation of the laboratory findings to clinically effective therapeutics.
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spelling pubmed-82096472021-06-28 Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers Farooqi, Ammad Ahmad Gulnara, Kapanova Mukhanbetzhanovna, Auyezova Ardak Datkhayev, Ubaidilla Kussainov, Abay Z. Adylova, Aima Noncoding RNA Res Article RUNX proteins have been shown to behave as “double-edge sword” in wide variety of cancers. Discovery of non-coding RNAs has played linchpin role in improving our understanding about the post-transcriptional regulation of different cell signaling pathways. Several new mechanistic insights and distinct modes of cross-regulation of RUNX proteins and non-coding RNAs have been highlighted by recent research. In this review we have attempted to provide an intricate interplay between non-coding RNAs and RUNX proteins in different cancers. Better conceptual and mechanistic understanding of layered regulation of RUNX proteins by non-coding RNAs will be helpful in effective translation of the laboratory findings to clinically effective therapeutics. KeAi Publishing 2021-05-30 /pmc/articles/PMC8209647/ /pubmed/34189363 http://dx.doi.org/10.1016/j.ncrna.2021.05.001 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Farooqi, Ammad Ahmad
Gulnara, Kapanova
Mukhanbetzhanovna, Auyezova Ardak
Datkhayev, Ubaidilla
Kussainov, Abay Z.
Adylova, Aima
Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers
title Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers
title_full Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers
title_fullStr Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers
title_full_unstemmed Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers
title_short Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers
title_sort regulation of runx proteins by long non-coding rnas and circular rnas in different cancers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209647/
https://www.ncbi.nlm.nih.gov/pubmed/34189363
http://dx.doi.org/10.1016/j.ncrna.2021.05.001
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