Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation

Drug development is hampered by poor target selection. Phenotypic screens using neurons differentiated from patient stem cells offer the possibility to validate known and discover novel disease targets in an unbiased fashion. To identify targets for managing hyperexcitability, a pathological feature...

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Detalles Bibliográficos
Autores principales: Huang, Xuan, Roet, Kasper C.D., Zhang, Liying, Brault, Amy, Berg, Allison P., Jefferson, Anne B., Klug-McLeod, Jackie, Leach, Karen L., Vincent, Fabien, Yang, Hongying, Coyle, Anthony J., Jones, Lyn H., Frost, Devlin, Wiskow, Ole, Chen, Kuchuan, Maeda, Rie, Grantham, Alyssa, Dornon, Mary K., Klim, Joseph R., Siekmann, Marco T., Zhao, Dongyi, Lee, Seungkyu, Eggan, Kevin, Woolf, Clifford J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209673/
https://www.ncbi.nlm.nih.gov/pubmed/34107252
http://dx.doi.org/10.1016/j.celrep.2021.109224

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