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Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum

Agenesis of the corpus callosum (AgCC) is a congenital brain malformation characterized by the complete or partial failure to develop the corpus callosum. Despite missing the largest white matter bundle connecting the left and right hemispheres of the brain, studies have shown preserved inter-hemisp...

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Autores principales: Shi, Minghui, Freitas, Lorena G.A., Spencer-Smith, Megan M., Kebets, Valeria, Anderson, Vicki, McIlroy, Alissandra, Wood, Amanda G., Leventer, Richard J., Van De Ville, Dimitri, Siffredi, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209843/
https://www.ncbi.nlm.nih.gov/pubmed/34130191
http://dx.doi.org/10.1016/j.nicl.2021.102709
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author Shi, Minghui
Freitas, Lorena G.A.
Spencer-Smith, Megan M.
Kebets, Valeria
Anderson, Vicki
McIlroy, Alissandra
Wood, Amanda G.
Leventer, Richard J.
Van De Ville, Dimitri
Siffredi, Vanessa
author_facet Shi, Minghui
Freitas, Lorena G.A.
Spencer-Smith, Megan M.
Kebets, Valeria
Anderson, Vicki
McIlroy, Alissandra
Wood, Amanda G.
Leventer, Richard J.
Van De Ville, Dimitri
Siffredi, Vanessa
author_sort Shi, Minghui
collection PubMed
description Agenesis of the corpus callosum (AgCC) is a congenital brain malformation characterized by the complete or partial failure to develop the corpus callosum. Despite missing the largest white matter bundle connecting the left and right hemispheres of the brain, studies have shown preserved inter-hemispheric communication in individuals with AgCC. It is likely that plasticity provides mechanisms for the brain to adjust in the context of AgCC, as the malformation disrupts programmed developmental brain processes very early on. A proposed candidate for neuroplastic response in individuals with AgCC is strengthening of intra-hemispheric structural connections. In the present study, we explore this hypothesis using a graph-based approach of the structural connectome, which enables intra- and inter-hemispheric analyses at multiple resolutions and quantification of structural characteristics through graph metrics. Structural graph metrics of 19 children with AgCC (13 with complete, 6 with partial AgCC) were compared to those of 29 typically developing controls (TDC). Associations between structural graph metrics and a wide range of neurobehavioral outcomes were examined using a multivariate data-driven approach (Partial Least Squares Correlation, PLSC). Our results provide new evidence suggesting structural strengthening of intra-hemispheric pathways as a neuroplastic response in the acallosal brain, and highlight regional variability in structural connectivity in children with AgCC compared to TDC. There was little evidence that structural graph properties in children with AgCC were associated with neurobehavioral outcomes. To our knowledge, this is the first report leveraging graph theory tools to explicitly characterize whole-brain intra- and inter-hemispheric structural connectivity in AgCC, opening avenues for future research on neuroplastic responses in AgCC.
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spelling pubmed-82098432021-06-25 Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum Shi, Minghui Freitas, Lorena G.A. Spencer-Smith, Megan M. Kebets, Valeria Anderson, Vicki McIlroy, Alissandra Wood, Amanda G. Leventer, Richard J. Van De Ville, Dimitri Siffredi, Vanessa Neuroimage Clin Regular Article Agenesis of the corpus callosum (AgCC) is a congenital brain malformation characterized by the complete or partial failure to develop the corpus callosum. Despite missing the largest white matter bundle connecting the left and right hemispheres of the brain, studies have shown preserved inter-hemispheric communication in individuals with AgCC. It is likely that plasticity provides mechanisms for the brain to adjust in the context of AgCC, as the malformation disrupts programmed developmental brain processes very early on. A proposed candidate for neuroplastic response in individuals with AgCC is strengthening of intra-hemispheric structural connections. In the present study, we explore this hypothesis using a graph-based approach of the structural connectome, which enables intra- and inter-hemispheric analyses at multiple resolutions and quantification of structural characteristics through graph metrics. Structural graph metrics of 19 children with AgCC (13 with complete, 6 with partial AgCC) were compared to those of 29 typically developing controls (TDC). Associations between structural graph metrics and a wide range of neurobehavioral outcomes were examined using a multivariate data-driven approach (Partial Least Squares Correlation, PLSC). Our results provide new evidence suggesting structural strengthening of intra-hemispheric pathways as a neuroplastic response in the acallosal brain, and highlight regional variability in structural connectivity in children with AgCC compared to TDC. There was little evidence that structural graph properties in children with AgCC were associated with neurobehavioral outcomes. To our knowledge, this is the first report leveraging graph theory tools to explicitly characterize whole-brain intra- and inter-hemispheric structural connectivity in AgCC, opening avenues for future research on neuroplastic responses in AgCC. Elsevier 2021-06-05 /pmc/articles/PMC8209843/ /pubmed/34130191 http://dx.doi.org/10.1016/j.nicl.2021.102709 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Shi, Minghui
Freitas, Lorena G.A.
Spencer-Smith, Megan M.
Kebets, Valeria
Anderson, Vicki
McIlroy, Alissandra
Wood, Amanda G.
Leventer, Richard J.
Van De Ville, Dimitri
Siffredi, Vanessa
Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum
title Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum
title_full Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum
title_fullStr Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum
title_full_unstemmed Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum
title_short Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum
title_sort intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209843/
https://www.ncbi.nlm.nih.gov/pubmed/34130191
http://dx.doi.org/10.1016/j.nicl.2021.102709
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