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The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks
Maintenance of genome stability suppresses cancer and other human diseases and is critical for organism survival. Inevitably, during a life span, multiple DNA lesions can arise due to the inherent instability of DNA molecules or due to endogenous or exogenous DNA damaging factors. To avoid malignant...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210011/ https://www.ncbi.nlm.nih.gov/pubmed/34316684 http://dx.doi.org/10.1093/narcan/zcaa004 |
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author | Loshchenova, Polina S Sergeeva, Svetlana V Fletcher, Sally C Dianov, Grigory L |
author_facet | Loshchenova, Polina S Sergeeva, Svetlana V Fletcher, Sally C Dianov, Grigory L |
author_sort | Loshchenova, Polina S |
collection | PubMed |
description | Maintenance of genome stability suppresses cancer and other human diseases and is critical for organism survival. Inevitably, during a life span, multiple DNA lesions can arise due to the inherent instability of DNA molecules or due to endogenous or exogenous DNA damaging factors. To avoid malignant transformation of cells with damaged DNA, multiple mechanisms have evolved to repair DNA or to detect and eradicate cells accumulating unrepaired DNA damage. In this review, we discuss recent findings on the role of Sp1 (specificity factor 1) in the detection and elimination of cells accumulating persistent DNA strand breaks. We also discuss how this mechanism may contribute to the maintenance of physiological populations of healthy cells in an organism, thus preventing cancer formation, and the possible application of these findings in cancer therapy. |
format | Online Article Text |
id | pubmed-8210011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82100112021-07-26 The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks Loshchenova, Polina S Sergeeva, Svetlana V Fletcher, Sally C Dianov, Grigory L NAR Cancer Short Review Maintenance of genome stability suppresses cancer and other human diseases and is critical for organism survival. Inevitably, during a life span, multiple DNA lesions can arise due to the inherent instability of DNA molecules or due to endogenous or exogenous DNA damaging factors. To avoid malignant transformation of cells with damaged DNA, multiple mechanisms have evolved to repair DNA or to detect and eradicate cells accumulating unrepaired DNA damage. In this review, we discuss recent findings on the role of Sp1 (specificity factor 1) in the detection and elimination of cells accumulating persistent DNA strand breaks. We also discuss how this mechanism may contribute to the maintenance of physiological populations of healthy cells in an organism, thus preventing cancer formation, and the possible application of these findings in cancer therapy. Oxford University Press 2020-03-14 /pmc/articles/PMC8210011/ /pubmed/34316684 http://dx.doi.org/10.1093/narcan/zcaa004 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Short Review Loshchenova, Polina S Sergeeva, Svetlana V Fletcher, Sally C Dianov, Grigory L The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks |
title | The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks |
title_full | The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks |
title_fullStr | The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks |
title_full_unstemmed | The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks |
title_short | The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks |
title_sort | role of sp1 in the detection and elimination of cells with persistent dna strand breaks |
topic | Short Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210011/ https://www.ncbi.nlm.nih.gov/pubmed/34316684 http://dx.doi.org/10.1093/narcan/zcaa004 |
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