Cargando…

Translation reprogramming by eIF3 linked to glioblastoma resistance

Intrinsic resistance to current therapies, leading to dismal clinical outcomes, is a hallmark of glioblastoma multiforme (GBM), the most common and aggressive brain tumor. Understanding the underlying mechanisms of such malignancy is, therefore, an urgent medical need. Deregulation of the protein tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bertorello, Juliette, Sesen, Julie, Gilhodes, Julia, Evrard, Solène, Courtade-Saïdi, Monique, Augustus, Meera, Uro-Coste, Emmanuelle, Toulas, Christine, Moyal, Elizabeth Cohen-Jonathan, Seva, Catherine, Dassi, Erik, Cammas, Anne, Skuli, Nicolas, Millevoi, Stefania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210094/ https://www.ncbi.nlm.nih.gov/pubmed/34316689 http://dx.doi.org/10.1093/narcan/zcaa020

Ejemplares similares

Int6/eIF3e Is Essential for Proliferation and Survival of Human Glioblastoma Cells
por: Sesen, Julie, et al.
Publicado: (2014)

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control
por: Jennings, Martin D., et al.
Publicado: (2016)

An interaction between eIF4A3 and eIF3g drives the internal initiation of translation
por: Chang, Jeeyoon, et al.
Publicado: (2023)

Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation
por: Kozel, Caitlin, et al.
Publicado: (2016)

Mechanisms of translational regulation by a human eIF5-mimic protein
por: Singh, Chingakham Ranjit, et al.
Publicado: (2011)

Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5
por: Loughran, Gary, et al.
Publicado: (2012)

Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions
por: Chen, Yi-Jiun, et al.
Publicado: (2010)

eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells
por: Song, Zhenxing, et al.
Publicado: (2022)

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
por: B’chir, Wafa, et al.
Publicado: (2013)

The eIF3 complex of Leishmania—subunit composition and mode of recruitment to different cap-binding complexes
por: Meleppattu, Shimi, et al.
Publicado: (2015)

Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression
por: Hiraishi, Hiroyuki, et al.
Publicado: (2014)

Large-scale movement of eIF3 domains during translation initiation modulate start codon selection
por: Llácer, Jose L, et al.
Publicado: (2021)

IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress
por: Thakor, Nehal, et al.
Publicado: (2012)

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins
por: Cridge, Andrew G., et al.
Publicado: (2010)

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions
por: Steinberger, Jutta, et al.
Publicado: (2020)

40S recruitment in the absence of eIF4G/4A by EMCV IRES refines the model for translation initiation on the archetype of Type II IRESs
por: Chamond, Nathalie, et al.
Publicado: (2014)

Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs
por: Chikashige, Yuji, et al.
Publicado: (2020)

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating P(i) release and conformational transitions of the preinitiation complex
por: Saini, Adesh K., et al.
Publicado: (2014)

PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation
por: Ivanova, Iglika G, et al.
Publicado: (2018)

Eukaryotic initiation factor (eIF) 3 mediates Barley Yellow Dwarf Viral mRNA 3′–5′ UTR interactions and 40S ribosomal subunit binding to facilitate cap-independent translation
por: Bhardwaj, Usha, et al.
Publicado: (2019)

In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures
por: Rahmoun, Massilva, et al.
Publicado: (2017)

Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling
por: Watzky, Manon, et al.
Publicado: (2022)

CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing
por: Kerschbamer, Emanuela, et al.
Publicado: (2022)

Custom human endogenous retroviruses dedicated microarray identifies self-induced HERV-W family elements reactivated in testicular cancer upon methylation control
por: Gimenez, Juliette, et al.
Publicado: (2010)

The transcription factor Sox5 modulates Sox10 function during melanocyte development
por: Stolt, C. Claus, et al.
Publicado: (2008)

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex
por: Thiaville, Michelle M., et al.
Publicado: (2008)

S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
por: André, Gaëlle, et al.
Publicado: (2008)

The CaMV transactivator/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis
por: Shivaprasad, Padubidri V., et al.
Publicado: (2008)

Expanded binding specificity of the human histone chaperone NASP
por: Wang, Huanyu, et al.
Publicado: (2008)

Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRγ
por: Song, Guisheng, et al.
Publicado: (2008)

Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
por: Roque, Alicia, et al.
Publicado: (2008)

Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk
por: Spatuzza, Carmen, et al.
Publicado: (2008)

Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
por: Ray, Sutapa, et al.
Publicado: (2008)

TAp73β and DNp73β activate the expression of the pro-survival caspase-2(S)
por: Toh, Wen Hong, et al.
Publicado: (2008)

The orphan receptor ERRα interferes with steroid signaling
por: Teyssier, Catherine, et al.
Publicado: (2008)

An intronic microRNA silences genes that are functionally antagonistic to its host gene
por: Barik, Sailen
Publicado: (2008)

Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements
por: Taylor, Jennifer M., et al.
Publicado: (2008)

A high-throughput percentage-of-binding strategy to measure binding energies in DNA–protein interactions: application to genome-scale site discovery
por: Wang, Xiaohu, et al.
Publicado: (2008)

The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation
por: Stefanovsky, Victor Y., et al.
Publicado: (2008)

Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription
por: Wang, Wen-Ling, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_jdstssdkuvv9cmdhl06h5dkn4l