Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity

Topoisomerase inhibitors are potent DNA damaging agents which are widely used in oncology, and they demonstrate robust synergistic tumor cell killing in combination with DNA repair inhibitors, including poly(ADP)-ribose polymerase (PARP) inhibitors. However, their use has been severely limited by th...

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Detalles Bibliográficos
Autores principales: Gayle, Sophia, Aiello, Robert, Leelatian, Nalin, Beckta, Jason M, Bechtold, Jane, Bourassa, Patricia, Csengery, Johanna, Maguire, Robert J, Marshall, Dan, Sundaram, Ranjini K, Van Doorn, Jinny, Jones, Kelli, Moore, Hunter, Lopresti-Morrow, Lori, Paradis, Timothy, Tylaska, Laurie, Zhang, Qing, Visca, Hannah, Reshetnyak, Yana K, Andreev, Oleg A, Engelman, Donald M, Glazer, Peter M, Bindra, Ranjit S, Paralkar, Vishwas M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210154/
https://www.ncbi.nlm.nih.gov/pubmed/34316708
http://dx.doi.org/10.1093/narcan/zcab021

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