A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells

The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC) stimulates the production of the pro-tumorigenic BCLAF1-L splice variant. We discovered a group of small molecules with an aminothiazole carboxamide core (GPS167, GPS192 and others) that decrease productio...

Descripción completa

Detalles Bibliográficos
Autores principales: Sohail, Muhammad, Shkreta, Lulzim, Toutant, Johanne, Rabea, Safwat, Babeu, Jean-Philippe, Huard, Caroline, Coulombe-Huntington, Jasmin, Delannoy, Aurélie, Placet, Morgane, Geha, Sameh, Gendron, Fernand-Pierre, Boudreau, François, Tyers, Mike, Grierson, David S, Chabot, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Cancer-specific RNAs and RNA Processing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210162/
https://www.ncbi.nlm.nih.gov/pubmed/34316707
http://dx.doi.org/10.1093/narcan/zcab019

Ejemplares similares

Ejemplares similares