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Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer

Chemotherapy is used as a standard-of-care against cancers that display high levels of inherent genome instability. Chemotherapy induces DNA damage and intensifies pressure on the DNA repair pathways that can lead to deregulation. There is an urgent clinical need to be able to track the emergence of...

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Detalles Bibliográficos
Autores principales:	Wiegmans, Adrian P, Ward, Ambber, Ivanova, Ekaterina, Duijf, Pascal H G, Adams, Mark N, Najib, Idris Mohd, Van Oosterhout, Romy, Sadowski, Martin C, Kelly, Greg, Morrical, Scott W, O’Byrne, Ken, Lee, Jason S, Richard, Derek J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210242/ https://www.ncbi.nlm.nih.gov/pubmed/34316709 http://dx.doi.org/10.1093/narcan/zcab022

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