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Profiling of ribose methylations in ribosomal RNA from diffuse large B-cell lymphoma patients for evaluation of ribosomes as drug targets

Cancer cells are addicted to ribosome biogenesis and high levels of translation. Thus, differential inhibition of cancer cells can be achieved by targeting aspects of ribosome biogenesis or ribosome function. Using RiboMeth-seq for profiling of the ∼112 2′-O-Me sites in human ribosomal RNA, we demon...

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Detalles Bibliográficos
Autores principales:	Krogh, Nicolai, Asmar, Fazila, Côme, Christophe, Munch-Petersen, Helga Fibiger, Grønbæk, Kirsten, Nielsen, Henrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Cancer-specific RNAs and RNA Processing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210301/ https://www.ncbi.nlm.nih.gov/pubmed/34316692 http://dx.doi.org/10.1093/narcan/zcaa035

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