Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression

BACKGROUND: Genome-wide association studies have identified many single nucleotide polymorphisms (SNPs) associated with increased risk for intracranial aneurysm (IA). However, how such variants affect gene expression within IA is poorly understood. We used publicly-available ChIP-Seq data to study c...

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Detalles Bibliográficos
Autores principales: Poppenberg, Kerry E., Zebraski, Haley R., Avasthi, Naval, Waqas, Muhammad, Siddiqui, Adnan H., Jarvis, James N., Tutino, Vincent M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210394/
https://www.ncbi.nlm.nih.gov/pubmed/34134708
http://dx.doi.org/10.1186/s12920-021-01007-9

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