Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology, and Target Identification of Thiowurtzine, a Potent Inhibitor of the Opioid Receptors and the Ion Channels

[Image: see text] The number of candidate molecules for new non-narcotic analgesics is extremely limited. Here, we report the identification of thiowurtzine, a new potent analgesic molecule with promising application in chronic pain treatment. We describe the chemical synthesis of this unique compou...

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Detalles Bibliográficos
Autores principales: Aguero, Stephanie, Megy, Simon, Eremina, Valeria V., Kalashnikov, Alexander I., Krylova, Svetlana G., Kulagina, Daria A., Lopatina, Ksenia A., Fournier, Mailys, Povetyeva, Tatyana N., Vorozhtsov, Alexander B., Sysolyatin, Sergey V., Zhdanov, Vadim V., Terreux, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210403/
https://www.ncbi.nlm.nih.gov/pubmed/34151118
http://dx.doi.org/10.1021/acsomega.1c01786

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