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Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake

Extracellular solutes in the central nervous system are exchanged between the interstitial fluid, the perivascular compartment, and the cerebrospinal fluid (CSF). The “glymphatic” mechanism proposes that the astrocyte water channel aquaporin-4 (AQP4) is a major determinant of solute transport betwee...

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Detalles Bibliográficos
Autores principales: Smith, Alex J., Akdemir, Gokhan, Wadhwa, Meetu, Song, Dan, Verkman, Alan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210582/
https://www.ncbi.nlm.nih.gov/pubmed/34128962
http://dx.doi.org/10.1085/jgp.202112898