Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes

Rationale: One of the most common metabolic defects in cancers is the deficiency in arginine synthesis, which has been exploited therapeutically. Yet, challenges remain, and the mechanisms of arginine-starvation induced killing are largely unclear. Here, we sought to demonstrate the underlying mecha...

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Detalles Bibliográficos
Autores principales: Hsu, Sheng-Chieh, Chen, Chia-Lin, Cheng, Mei-Ling, Chu, Cheng-Ying, Changou, Chun A., Yu, Yen-Ling, Yeh, Shauh-Der, Kuo, Tse-Chun, Kuo, Cheng-Chin, Chuu, Chih-Pin, Li, Chien-Feng, Wang, Lu-Hai, Chen, Hong-Wu, Yen, Yun, Ann, David K., Wang, Hung-Jung, Kung, Hsing-Jien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210599/
https://www.ncbi.nlm.nih.gov/pubmed/34158865
http://dx.doi.org/10.7150/thno.54695

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