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Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production

Uncialamycin (UCM) belongs to the anthraquinone-fused subfamily of 10-membered enediyne natural products that exhibits an extraordinary cytotoxicity against a wide spectrum of human cancer cell lines. Antibody-drug conjugates, utilizing synthetic analogues of UCM as payloads, are in preclinical deve...

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Detalles Bibliográficos
Autores principales:	Hindra, Yang, Dong, Luo, Jun, Huang, Tingting, Yan, Xiaohui, Adhikari, Ajeeth, Teijaro, Christiana N, Ge, Huiming, Shen, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Natural Products
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210685/ https://www.ncbi.nlm.nih.gov/pubmed/33739406 http://dx.doi.org/10.1093/jimb/kuab025

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