EVI1 activates tumor-promoting transcriptional enhancers in pancreatic cancer

Cancer cells utilize epigenetic alterations to acquire autonomous capabilities for tumor maintenance. Here, we show that pancreatic ductal adenocarcinoma (PDA) cells utilize super-enhancers (SEs) to activate the transcription factor EVI1 (ecotropic viral integration site 1) gene, resulting in activa...

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Detalles Bibliográficos
Autores principales: Kim, Hwa-Ryeon, Yim, Juhye, Yoo, Hye-Been, Lee, Seung Eon, Oh, Sumin, Jung, Sungju, Hwang, Chang-il, Shin, Dong-Myung, Kim, TaeSoo, Yoo, Kyung Hyun, Kim, You-Sun, Lee, Han-Woong, Roe, Jae-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210884/
https://www.ncbi.nlm.nih.gov/pubmed/34316710
http://dx.doi.org/10.1093/narcan/zcab023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210884/
https://www.ncbi.nlm.nih.gov/pubmed/34316710
http://dx.doi.org/10.1093/narcan/zcab023

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