Pharmacogenetics to Avoid Loss of Hearing (PALOH) trial: a protocol for a prospective observational implementation trial

INTRODUCTION: In conjunction with a beta-lactam, aminoglycosides are the first-choice antibiotic for empirical treatment of sepsis in the neonatal period. The m.1555A>G variant predisposes to ototoxicity after aminoglycoside administration and has a prevalence of 1 in 500. Current genetic testing...

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Detalles Bibliográficos
Autores principales: McDermott, John Henry, Mahood, Rachel, Stoddard, Duncan, Mahaveer, Ajit, Turner, Mark A, Corry, Rachel, Garlick, Julia, Miele, Gino, Ainsworth, Shaun, Kemp, Laura, Bruce, Iain, Body, Richard, Ulph, Fiona, Macleod, Rhona, Harvey, Karen, Booth, Nicola, Roberts, Peter, Wilson, Paul, Newman, William G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211036/
https://www.ncbi.nlm.nih.gov/pubmed/34135034
http://dx.doi.org/10.1136/bmjopen-2020-044457

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