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Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis

AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor. Activation of AMPK leads to a number of metabolic benefits, including improved mitochondrial function in skeletal muscle and lowering of serum glucose levels in type-2 diabetes models. However, direct activation of AMP...

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Detalles Bibliográficos
Autores principales:	Park, Sung-Jun, Ahmad, Faiyaz, Bahde, Robert J., Philp, Andrew, Kim, Jeonghan, Huang, Tianjiao, Kim, Myung K., Trenkle, William C., Chung, Jay H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211267/ https://www.ncbi.nlm.nih.gov/pubmed/34138962 http://dx.doi.org/10.1371/journal.pone.0253269

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