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Structurally distinct external solvent-exposed domains drive replication of major human prions

There is a limited understanding of structural attributes that encode the iatrogenic transmissibility and various phenotypes of prions causing the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD). Here we report the detailed structural differences between major sCJD MM1, MM...

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Detalles Bibliográficos
Autores principales:	Siddiqi, Mohammad Khursheed, Kim, Chae, Haldiman, Tracy, Kacirova, Miroslava, Wang, Benlian, Bohon, Jen, Chance, Mark R., Kiselar, Janna, Safar, Jiri G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211289/ https://www.ncbi.nlm.nih.gov/pubmed/34138981 http://dx.doi.org/10.1371/journal.ppat.1009642

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