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The role of myeloid‐derived suppressor cells in gastrointestinal cancer

Gastrointestinal (GI) cancer encompasses a range of malignancies that originate in the digestive system, which together represent the most common form of cancer diagnosed worldwide. However, despite numerous advances in both diagnostics and treatment, the incidence and mortality rate of GI cancer ar...

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Detalles Bibliográficos
Autores principales: Cui, Cheng, Lan, Penglin, Fu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211353/
https://www.ncbi.nlm.nih.gov/pubmed/33773092
http://dx.doi.org/10.1002/cac2.12156
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author Cui, Cheng
Lan, Penglin
Fu, Li
author_facet Cui, Cheng
Lan, Penglin
Fu, Li
author_sort Cui, Cheng
collection PubMed
description Gastrointestinal (GI) cancer encompasses a range of malignancies that originate in the digestive system, which together represent the most common form of cancer diagnosed worldwide. However, despite numerous advances in both diagnostics and treatment, the incidence and mortality rate of GI cancer are on the rise. Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that increase in number under certain pathological conditions, such as infection and inflammation, and this expansion is of particular relevance to cancer. MDSCs are heavily involved in the regulation of the immune system and act to dampen its response to tumors, favoring the escape of tumor cells from immunosurveillance and increasing both metastasis and recurrence. Several recent studies have supported the use of MDSCs as a prognostic and predictive biomarker in patients with cancer, and potentially as a novel treatment target. In the present review, the mechanisms underlying the immunosuppressive functions of MDSCs are described, and recent researches concerning the involvement of MDSCs in the progression, prognosis, and therapies of GI cancer are reviewed. The aim of this work was to present the development of novel treatments targeting MDSCs in GI cancer in the hope of improving outcomes for patients with this condition.
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spelling pubmed-82113532021-06-25 The role of myeloid‐derived suppressor cells in gastrointestinal cancer Cui, Cheng Lan, Penglin Fu, Li Cancer Commun (Lond) Review Gastrointestinal (GI) cancer encompasses a range of malignancies that originate in the digestive system, which together represent the most common form of cancer diagnosed worldwide. However, despite numerous advances in both diagnostics and treatment, the incidence and mortality rate of GI cancer are on the rise. Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that increase in number under certain pathological conditions, such as infection and inflammation, and this expansion is of particular relevance to cancer. MDSCs are heavily involved in the regulation of the immune system and act to dampen its response to tumors, favoring the escape of tumor cells from immunosurveillance and increasing both metastasis and recurrence. Several recent studies have supported the use of MDSCs as a prognostic and predictive biomarker in patients with cancer, and potentially as a novel treatment target. In the present review, the mechanisms underlying the immunosuppressive functions of MDSCs are described, and recent researches concerning the involvement of MDSCs in the progression, prognosis, and therapies of GI cancer are reviewed. The aim of this work was to present the development of novel treatments targeting MDSCs in GI cancer in the hope of improving outcomes for patients with this condition. John Wiley and Sons Inc. 2021-03-27 /pmc/articles/PMC8211353/ /pubmed/33773092 http://dx.doi.org/10.1002/cac2.12156 Text en © 2021 The Authors. Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat‐sen University Cancer Center https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Cui, Cheng
Lan, Penglin
Fu, Li
The role of myeloid‐derived suppressor cells in gastrointestinal cancer
title The role of myeloid‐derived suppressor cells in gastrointestinal cancer
title_full The role of myeloid‐derived suppressor cells in gastrointestinal cancer
title_fullStr The role of myeloid‐derived suppressor cells in gastrointestinal cancer
title_full_unstemmed The role of myeloid‐derived suppressor cells in gastrointestinal cancer
title_short The role of myeloid‐derived suppressor cells in gastrointestinal cancer
title_sort role of myeloid‐derived suppressor cells in gastrointestinal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211353/
https://www.ncbi.nlm.nih.gov/pubmed/33773092
http://dx.doi.org/10.1002/cac2.12156
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