Cargando…
Predicting 3D genome folding from DNA sequence with Akita
In interphase, the human genome sequence folds in three dimensions into a rich variety of locus-specific contact patterns. Cohesin and CTCF are key regulators; perturbing the levels of either greatly disrupts genome-wide folding as assayed by chromosome conformation capture methods. Still, how a giv...
Autores principales: | Fudenberg, Geoff, Kelley, David R., Pollard, Katherine S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211359/ https://www.ncbi.nlm.nih.gov/pubmed/33046897 http://dx.doi.org/10.1038/s41592-020-0958-x |
Ejemplares similares
-
Genome-wide variability in recombination activity is associated with meiotic chromatin organization
por: Jin, Xiaofan, et al.
Publicado: (2021) -
Chromatin features constrain structural variation across evolutionary timescales
por: Fudenberg, Geoff, et al.
Publicado: (2019) -
In silico discovery of repetitive elements as key sequence determinants of 3D genome folding
por: Gunsalus, Laura M., et al.
Publicado: (2023) -
Suicide in Akita Prefecture, Japan
por: Fushimi, Masahito, et al.
Publicado: (2006) -
Molecular basis of CTCF binding polarity in genome folding
por: Nora, Elphège P., et al.
Publicado: (2020)