Cargando…

A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study

Prostate cancer (PCa) is associated with advanced age, but how age contributes to prostate carcinogenesis remains unknown. The prostate-specific Pten conditional knockout mouse model closely imitates human PCa initiation and progression. To better understand how age impacts PCa in an experimental mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Sen, Zhang, Bing, Rowan, Brian G., Jazwinski, S. Michal, Abdel-Mageed, Asim B., Steele, Chad, Wang, Alun R., Sartor, Oliver, Niu, Tianhua, Zhang, Qiuyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211560/ https://www.ncbi.nlm.nih.gov/pubmed/34150854 http://dx.doi.org/10.3389/fmolb.2021.696537

Ejemplares similares

Age-Related Increased Onset and Progression of Prostate Cancer Is Revealed in Novel Pten-Null Mouse Models
por: Zhang, Qiuyang, et al.
Publicado: (2020)

AGE-RELATED ELEVATED CD4+ T HELPER 17 CELL RESPONSE PROMOTES PROSTATE CANCER CELL GROWTH, MIGRATION, AND INVASION
por: Zhang, Qiuyang, et al.
Publicado: (2019)

Endogenous PTEN acts as the key determinant for mTOR inhibitor sensitivity by inducing the stress-sensitized PTEN-mediated death axis in KSHV-associated malignant cells
por: Das, Piyanki, et al.
Publicado: (2023)

Proteomic profiling of eIF3a conditional knockout mice
por: Zhuo, Wei, et al.
Publicado: (2023)

An Integrated Computational and Experimental Approach to Identifying Inhibitors for SARS-CoV-2 3CL Protease
por: Zhai, Tianhua, et al.
Publicado: (2021)

Biomarker discovery in galactosemia: Metabolomics with UPLC/HRMS in dried blood spots
por: Alodaib, Ahmad N., et al.
Publicado: (2023)

Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
por: Varshavi, Dorsa, et al.
Publicado: (2018)

Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases
por: Bleeker, Joosje, et al.
Publicado: (2022)

MiR-520a-3p Inhibited Macrophage Polarization and Promoted the Development of Atherosclerosis via Targeting UVRAG in Apolipoprotein E Knockout Mice
por: Qi, Jing Rui, et al.
Publicado: (2021)

Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kβ inhibition on metabolic pathway activities in a PTEN null breast cancer cell line
por: Lackner, Marcel, et al.
Publicado: (2022)

Single-gene knockout-coupled omics analysis identifies C9orf85 and CXorf38 as two uncharacterized human proteins associated with ZIP8 malfunction
por: Tan, Heng Wee, et al.
Publicado: (2022)

Establishment of Novel Prostate Cancer Risk Subtypes and A Twelve-Gene Prognostic Model
por: Zhang, Enchong, et al.
Publicado: (2021)

Untargeted Metabolomics Study of Three Matrices: Seminal Fluid, Urine, and Serum to Search the Potential Indicators of Prostate Cancer
por: Buszewska-Forajta, Magdalena, et al.
Publicado: (2022)

Editorial: Heterogeneity and plasticity of prostate cancer
por: Culig, Zoran, et al.
Publicado: (2023)

Dynamics of Cellular Plasticity in Prostate Cancer Progression
por: Tiwari, Ritika, et al.
Publicado: (2020)

Integrative Analysis of MALT1 as a Potential Therapeutic Target for Prostate Cancer and its Immunological Role in Pan-Cancer
por: Tan, Haotian, et al.
Publicado: (2021)

CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer
por: Nagaya, Naoya, et al.
Publicado: (2020)

Exercise-Induced Extracellular Vesicles Delay the Progression of Prostate Cancer
por: Sadovska, Lilite, et al.
Publicado: (2022)

Identification of a DNA Repair Gene Signature and Establishment of a Prognostic Nomogram Predicting Biochemical-Recurrence-Free Survival of Prostate Cancer
por: Long, Gongwei, et al.
Publicado: (2021)

Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p
por: Zeng, Liang, et al.
Publicado: (2021)

Roles of Key Epigenetic Regulators in the Gene Transcription and Progression of Prostate Cancer
por: Deng, Tanggang, et al.
Publicado: (2021)

Cabozantinib and IL-27 combinatorial therapy for bone-metastatic prostate cancer
por: Kumar, Shreya, et al.
Publicado: (2023)

Structure and Characterization of a Covalent Inhibitor of Src Kinase
por: Gurbani, Deepak, et al.
Publicado: (2020)

CD38-Induced Apoptosis and Mitochondrial Damage is Restored by Nicotinamide in Prostate Cancer
por: Kanayama, Mayuko, et al.
Publicado: (2022)

Decoding the Role of Epigenetics in Breast Cancer Using Formal Modeling and Machine-Learning Methods
por: Asim, Ayesha, et al.
Publicado: (2022)

Identification of a Novel Ferroptosis Inducer for Gastric Cancer Treatment Using Drug Repurposing Strategy
por: Zhang, Jinping, et al.
Publicado: (2022)

A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression
por: Zhang, Qiuyang, et al.
Publicado: (2022)

Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer
por: Pinto, Catarina I. G., et al.
Publicado: (2020)

Comprehensive Characterization of Ageing-Relevant Subtypes Associated With Different Tumorigenesis and Tumor Microenvironment in Prostate Cancer
por: Huang, Liang, et al.
Publicado: (2022)

Identification of Pyroptosis-Related Gene Signatures and Construction of the Risk Model to Predict BCR in Prostate Cancer
por: Wang, Miaomiao, et al.
Publicado: (2022)

Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies
por: Bajo-Santos, Cristina, et al.
Publicado: (2023)

Deep multi-modal intermediate fusion of clinical record and time series data in mortality prediction
por: Niu, Ke, et al.
Publicado: (2023)

Modeling of the thermal properties of SARS-CoV-2 S-protein
por: Niu, Ziyuan, et al.
Publicado: (2022)

The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer
por: Shen, Dexin, et al.
Publicado: (2022)

Influence of Androgen Deprivation Therapy on the PD-L1 Expression and Immune Activity in Prostate Cancer Tissue
por: Sommer, Ulrich, et al.
Publicado: (2022)

Molecular Docking and Molecular Dynamics Aided Virtual Search of OliveNet™ Directory for Secoiridoids to Combat SARS-CoV-2 Infection and Associated Hyperinflammatory Responses
por: Thangavel, Neelaveni, et al.
Publicado: (2021)

Cytotopic (Cyto-) IL-15 as a New Immunotherapy for Prostate Cancer: Recombinant Production in Escherichia coli and Purification
por: Esteves, Ana M., et al.
Publicado: (2021)

A Novel Gene Signature Associated With “E2F Target” Pathway for Predicting the Prognosis of Prostate Cancer
por: Xia, Haoran, et al.
Publicado: (2022)

Polymorphisms in Genes Encoding Glutathione Transferase Pi and Glutathione Transferase Omega Influence Prostate Cancer Risk and Prognosis
por: Santric, Veljko, et al.
Publicado: (2021)

Identification of a Novel Protein-Based Signature to Improve Prognosis Prediction in Renal Clear Cell Carcinoma
por: Chu, Guangdi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o9etnuei9qfe8188rs6qi499re