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Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye?

PURPOSE: Use of automated perfusion software has gained importance for imaging of stroke patients for mechanical thrombectomy (MT). We aim to compare four perfusion software packages: 1) with respect to their association with 3‑month functional outcome after successful reperfusion with MT in compari...

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Autores principales: Psychogios, Marios-Nikos, Sporns, Peter B., Ospel, Johanna, Katsanos, Aristeidis H., Kabiri, Reza, Flottmann, Fabian A., Menon, Bijoy K., Horn, Mackenzie, Liebeskind, David S., Honda, Tristan, Ribo, Marc, Ruiz, Manuel Requena, Kabbasch, Christoph, Lichtenstein, Thorsten, Maurer, Christoph J., Berlis, Ansgar, Hellstern, Victoria, Henkes, Hans, Möhlenbruch, Markus A., Seker, Fatih, Ernst, Marielle S., Liman, Jan, Tsivgoulis, Georgios, Brehm, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211603/
https://www.ncbi.nlm.nih.gov/pubmed/33216157
http://dx.doi.org/10.1007/s00062-020-00974-3
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author Psychogios, Marios-Nikos
Sporns, Peter B.
Ospel, Johanna
Katsanos, Aristeidis H.
Kabiri, Reza
Flottmann, Fabian A.
Menon, Bijoy K.
Horn, Mackenzie
Liebeskind, David S.
Honda, Tristan
Ribo, Marc
Ruiz, Manuel Requena
Kabbasch, Christoph
Lichtenstein, Thorsten
Maurer, Christoph J.
Berlis, Ansgar
Hellstern, Victoria
Henkes, Hans
Möhlenbruch, Markus A.
Seker, Fatih
Ernst, Marielle S.
Liman, Jan
Tsivgoulis, Georgios
Brehm, Alex
author_facet Psychogios, Marios-Nikos
Sporns, Peter B.
Ospel, Johanna
Katsanos, Aristeidis H.
Kabiri, Reza
Flottmann, Fabian A.
Menon, Bijoy K.
Horn, Mackenzie
Liebeskind, David S.
Honda, Tristan
Ribo, Marc
Ruiz, Manuel Requena
Kabbasch, Christoph
Lichtenstein, Thorsten
Maurer, Christoph J.
Berlis, Ansgar
Hellstern, Victoria
Henkes, Hans
Möhlenbruch, Markus A.
Seker, Fatih
Ernst, Marielle S.
Liman, Jan
Tsivgoulis, Georgios
Brehm, Alex
author_sort Psychogios, Marios-Nikos
collection PubMed
description PURPOSE: Use of automated perfusion software has gained importance for imaging of stroke patients for mechanical thrombectomy (MT). We aim to compare four perfusion software packages: 1) with respect to their association with 3‑month functional outcome after successful reperfusion with MT in comparison to visual Cerebral Blood Volume - Alberta Stroke Program Early CT Score (CBV-ASPECTS) and collateral scoring and 2) with respect to their agreement in estimation of core and penumbra volume. METHODS: This retrospective, multicenter cohort study (2015–2019) analyzed data from 8 centers. We included patients who were functionally independent before and underwent successful MT of the middle cerebral artery. Primary outcome measurements were the relationship of core and penumbra volume calculated by each software, qualitative assessment of collaterals and CBV-APECTS with 3‑month functional outcome and disability (modified Rankin scale >2). Quantitative differences between perfusion software measurements were also assessed. RESULTS: A total of 215 patients (57% women, median age 77 years) from 8 centers fulfilled the inclusion criteria. Multivariable analyses showed a significant association of RAPID core (common odds ratio, cOR 1.02; p = 0.015), CBV-ASPECTS (cOR 0.78; p = 0.007) and collaterals (cOR 0.78; p = 0.001) with 3‑month functional outcome (shift analysis), while RAPID core (OR 1.02; p = 0.018), CBV-ASPECTS (OR 0.77; p = 0.024), collaterals (OR 0.78; p = 0.007) and OLEA core (OR 1.02; p = 0.029) were significantly associated with 3‑month functional disability. Mean differences on core estimates between VEOcore and RAPID were 13.4 ml, between syngo.via and RAPID 30.0 ml and between OLEA and RAPID −3.2 ml. CONCLUSION: Collateral scoring, CBV-ASPECTS and RAPID were independently associated with functional outcome at 90 days. Core and Penumbra estimates using automated software packages varied significantly and should therefore be used with caution. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00062-020-00974-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-82116032021-07-01 Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye? Psychogios, Marios-Nikos Sporns, Peter B. Ospel, Johanna Katsanos, Aristeidis H. Kabiri, Reza Flottmann, Fabian A. Menon, Bijoy K. Horn, Mackenzie Liebeskind, David S. Honda, Tristan Ribo, Marc Ruiz, Manuel Requena Kabbasch, Christoph Lichtenstein, Thorsten Maurer, Christoph J. Berlis, Ansgar Hellstern, Victoria Henkes, Hans Möhlenbruch, Markus A. Seker, Fatih Ernst, Marielle S. Liman, Jan Tsivgoulis, Georgios Brehm, Alex Clin Neuroradiol Original Article PURPOSE: Use of automated perfusion software has gained importance for imaging of stroke patients for mechanical thrombectomy (MT). We aim to compare four perfusion software packages: 1) with respect to their association with 3‑month functional outcome after successful reperfusion with MT in comparison to visual Cerebral Blood Volume - Alberta Stroke Program Early CT Score (CBV-ASPECTS) and collateral scoring and 2) with respect to their agreement in estimation of core and penumbra volume. METHODS: This retrospective, multicenter cohort study (2015–2019) analyzed data from 8 centers. We included patients who were functionally independent before and underwent successful MT of the middle cerebral artery. Primary outcome measurements were the relationship of core and penumbra volume calculated by each software, qualitative assessment of collaterals and CBV-APECTS with 3‑month functional outcome and disability (modified Rankin scale >2). Quantitative differences between perfusion software measurements were also assessed. RESULTS: A total of 215 patients (57% women, median age 77 years) from 8 centers fulfilled the inclusion criteria. Multivariable analyses showed a significant association of RAPID core (common odds ratio, cOR 1.02; p = 0.015), CBV-ASPECTS (cOR 0.78; p = 0.007) and collaterals (cOR 0.78; p = 0.001) with 3‑month functional outcome (shift analysis), while RAPID core (OR 1.02; p = 0.018), CBV-ASPECTS (OR 0.77; p = 0.024), collaterals (OR 0.78; p = 0.007) and OLEA core (OR 1.02; p = 0.029) were significantly associated with 3‑month functional disability. Mean differences on core estimates between VEOcore and RAPID were 13.4 ml, between syngo.via and RAPID 30.0 ml and between OLEA and RAPID −3.2 ml. CONCLUSION: Collateral scoring, CBV-ASPECTS and RAPID were independently associated with functional outcome at 90 days. Core and Penumbra estimates using automated software packages varied significantly and should therefore be used with caution. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00062-020-00974-3) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-11-20 2021 /pmc/articles/PMC8211603/ /pubmed/33216157 http://dx.doi.org/10.1007/s00062-020-00974-3 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Psychogios, Marios-Nikos
Sporns, Peter B.
Ospel, Johanna
Katsanos, Aristeidis H.
Kabiri, Reza
Flottmann, Fabian A.
Menon, Bijoy K.
Horn, Mackenzie
Liebeskind, David S.
Honda, Tristan
Ribo, Marc
Ruiz, Manuel Requena
Kabbasch, Christoph
Lichtenstein, Thorsten
Maurer, Christoph J.
Berlis, Ansgar
Hellstern, Victoria
Henkes, Hans
Möhlenbruch, Markus A.
Seker, Fatih
Ernst, Marielle S.
Liman, Jan
Tsivgoulis, Georgios
Brehm, Alex
Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye?
title Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye?
title_full Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye?
title_fullStr Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye?
title_full_unstemmed Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye?
title_short Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye?
title_sort automated perfusion calculations vs. visual scoring of collaterals and cbv-aspects: has the machine surpassed the eye?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211603/
https://www.ncbi.nlm.nih.gov/pubmed/33216157
http://dx.doi.org/10.1007/s00062-020-00974-3
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