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The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation

BACKGROUND: Methylnaltrexone, a peripherally acting µ-opioid receptor antagonist approved for the treatment of opioid-induced constipation (OIC), has restricted diffusion across the blood–brain barrier (BBB) and has not been demonstrated to impact opioid-induced central analgesia. Age-related change...

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Detalles Bibliográficos
Autores principales:	Liao, Solomon S., Slatkin, Neal E., Stambler, Nancy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211613/ https://www.ncbi.nlm.nih.gov/pubmed/33788162 http://dx.doi.org/10.1007/s40266-021-00850-w

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