A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells

An array of SARS-CoV-2 virus variants have been isolated, propagated and used in in vitro assays, in vivo animal studies and human clinical trials. Observations of working stocks of SARS-CoV-2 suggest that sequential propagation in Vero cells leads to critical changes in the region of the furin clea...

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Detalles Bibliográficos
Autores principales: Funnell, Simon G. P., Afrough, Babak, Baczenas, John James, Berry, Neil, Bewley, Kevin R., Bradford, Rebecca, Florence, Clint, Duff, Yann Le, Lewis, Mark, Moriarty, Ryan V., Connor, Shelby L. O., Osman, Karen L., Pullan, Steven, Rashid, Sujatha, Richards, Kevin S., Stemple, Kimberly J., Knezevic, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211640/
https://www.ncbi.nlm.nih.gov/pubmed/34140522
http://dx.doi.org/10.1038/s41541-021-00346-z

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