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M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity

Dysfunctional megakaryopoiesis hampers platelet production, which is closely associated with thrombocytopenia (PT). Macrophages (MФs) are crucial cellular components in the bone marrow (BM) microenvironment. However, the specific effects of M1 MФs or M2 MФs on regulating megakaryocytes (MKs) are lar...

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Detalles Bibliográficos
Autores principales:	Zhao, Hong-Yan, Zhang, Yuan-Yuan, Xing, Tong, Tang, Shu-Qian, Wen, Qi, Lyu, Zhong-Shi, Lv, Meng, Wang, Yu, Xu, Lan-Ping, Zhang, Xiao-Hui, Kong, Yuan, Huang, Xiao-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211642/ https://www.ncbi.nlm.nih.gov/pubmed/34140465 http://dx.doi.org/10.1038/s41392-021-00627-y

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