Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection o...

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Autores principales: Oliva Chávez, Adela S., Wang, Xiaowei, Marnin, Liron, Archer, Nathan K., Hammond, Holly L., Carroll, Erin E. McClure, Shaw, Dana K., Tully, Brenden G., Buskirk, Amanda D., Ford, Shelby L., Butler, L. Rainer, Shahi, Preeti, Morozova, Kateryna, Clement, Cristina C., Lawres, Lauren, Neal, Anya J. O’, Mamoun, Choukri Ben, Mason, Kathleen L., Hobbs, Brandi E., Scoles, Glen A., Barry, Eileen M., Sonenshine, Daniel E., Pal, Utpal, Valenzuela, Jesus G., Sztein, Marcelo B., Pasetti, Marcela F., Levin, Michael L., Kotsyfakis, Michail, Jay, Steven M., Huntley, Jason F., Miller, Lloyd S., Santambrogio, Laura, Pedra, Joao H. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211691/
https://www.ncbi.nlm.nih.gov/pubmed/34140472
http://dx.doi.org/10.1038/s41467-021-23900-8
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author Oliva Chávez, Adela S.
Wang, Xiaowei
Marnin, Liron
Archer, Nathan K.
Hammond, Holly L.
Carroll, Erin E. McClure
Shaw, Dana K.
Tully, Brenden G.
Buskirk, Amanda D.
Ford, Shelby L.
Butler, L. Rainer
Shahi, Preeti
Morozova, Kateryna
Clement, Cristina C.
Lawres, Lauren
Neal, Anya J. O’
Mamoun, Choukri Ben
Mason, Kathleen L.
Hobbs, Brandi E.
Scoles, Glen A.
Barry, Eileen M.
Sonenshine, Daniel E.
Pal, Utpal
Valenzuela, Jesus G.
Sztein, Marcelo B.
Pasetti, Marcela F.
Levin, Michael L.
Kotsyfakis, Michail
Jay, Steven M.
Huntley, Jason F.
Miller, Lloyd S.
Santambrogio, Laura
Pedra, Joao H. F.
author_facet Oliva Chávez, Adela S.
Wang, Xiaowei
Marnin, Liron
Archer, Nathan K.
Hammond, Holly L.
Carroll, Erin E. McClure
Shaw, Dana K.
Tully, Brenden G.
Buskirk, Amanda D.
Ford, Shelby L.
Butler, L. Rainer
Shahi, Preeti
Morozova, Kateryna
Clement, Cristina C.
Lawres, Lauren
Neal, Anya J. O’
Mamoun, Choukri Ben
Mason, Kathleen L.
Hobbs, Brandi E.
Scoles, Glen A.
Barry, Eileen M.
Sonenshine, Daniel E.
Pal, Utpal
Valenzuela, Jesus G.
Sztein, Marcelo B.
Pasetti, Marcela F.
Levin, Michael L.
Kotsyfakis, Michail
Jay, Steven M.
Huntley, Jason F.
Miller, Lloyd S.
Santambrogio, Laura
Pedra, Joao H. F.
author_sort Oliva Chávez, Adela S.
collection PubMed
description Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases.
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spelling pubmed-82116912021-07-01 Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection Oliva Chávez, Adela S. Wang, Xiaowei Marnin, Liron Archer, Nathan K. Hammond, Holly L. Carroll, Erin E. McClure Shaw, Dana K. Tully, Brenden G. Buskirk, Amanda D. Ford, Shelby L. Butler, L. Rainer Shahi, Preeti Morozova, Kateryna Clement, Cristina C. Lawres, Lauren Neal, Anya J. O’ Mamoun, Choukri Ben Mason, Kathleen L. Hobbs, Brandi E. Scoles, Glen A. Barry, Eileen M. Sonenshine, Daniel E. Pal, Utpal Valenzuela, Jesus G. Sztein, Marcelo B. Pasetti, Marcela F. Levin, Michael L. Kotsyfakis, Michail Jay, Steven M. Huntley, Jason F. Miller, Lloyd S. Santambrogio, Laura Pedra, Joao H. F. Nat Commun Article Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases. Nature Publishing Group UK 2021-06-17 /pmc/articles/PMC8211691/ /pubmed/34140472 http://dx.doi.org/10.1038/s41467-021-23900-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Oliva Chávez, Adela S.
Wang, Xiaowei
Marnin, Liron
Archer, Nathan K.
Hammond, Holly L.
Carroll, Erin E. McClure
Shaw, Dana K.
Tully, Brenden G.
Buskirk, Amanda D.
Ford, Shelby L.
Butler, L. Rainer
Shahi, Preeti
Morozova, Kateryna
Clement, Cristina C.
Lawres, Lauren
Neal, Anya J. O’
Mamoun, Choukri Ben
Mason, Kathleen L.
Hobbs, Brandi E.
Scoles, Glen A.
Barry, Eileen M.
Sonenshine, Daniel E.
Pal, Utpal
Valenzuela, Jesus G.
Sztein, Marcelo B.
Pasetti, Marcela F.
Levin, Michael L.
Kotsyfakis, Michail
Jay, Steven M.
Huntley, Jason F.
Miller, Lloyd S.
Santambrogio, Laura
Pedra, Joao H. F.
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
title Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
title_full Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
title_fullStr Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
title_full_unstemmed Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
title_short Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
title_sort tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211691/
https://www.ncbi.nlm.nih.gov/pubmed/34140472
http://dx.doi.org/10.1038/s41467-021-23900-8
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